MaxiKα Activators
The MaxiKα Activators represent a diverse class of chemicals designed to modulate the activity of the MaxiKα channel, a large-conductance calcium-activated potassium channel with crucial roles in cellular physiology. These activators employ various mechanisms to either directly or indirectly influence MaxiKα channel function, offering valuable insights into the intricate regulatory pathways governing cellular membrane potential and ion flux. Tocainide, a sodium channel blocker, indirectly impacts MaxiKα activation by altering membrane excitability. Through the reduction of sodium influx, Tocainide initiates cascading effects on cellular signaling, culminating in increased MaxiKα channel activity. This modulation holds implications for smooth muscle relaxation and neuronal processes, providing a nuanced understanding of the interplay between ion channels and membrane dynamics.
In contrast, compounds like Cromakalim, Pinacidil, and SKA-121 operate as direct MaxiKα activators by promoting potassium efflux. These potassium channel openers enhance cellular membrane potential and contribute to the activation of MaxiKα channels, influencing processes such as smooth muscle relaxation and neuronal excitability. Furthermore, Riociguat, a stimulator of soluble guanylate cyclase (sGC), indirectly activates MaxiKα channels by elevating cGMP levels. The cGMP-dependent pathway modulates MaxiKα activity, shedding light on the intricate signaling cascades influencing cellular functions. Naringenin, a flavonoid, takes an indirect approach by modulating cellular signaling pathways, impacting MaxiKα channels and contributing to changes in cellular membrane potential. This variety of mechanisms employed by MaxiKα activators showcases the complexity of ion channel regulation and offers a nuanced toolkit for researchers probing the intricacies of cellular physiology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(±)-Cromakalim | 94470-67-4 | sc-217958 | 25 mg | $428.00 | ||
Cromakalim, a potassium channel opener, directly activates MaxiKα channels, enhancing potassium efflux and influencing cellular membrane potential. This activation has implications for smooth muscle relaxation and cardiovascular regulation, making Cromakalim a valuable tool in studying MaxiKα channel activation. | ||||||
Pinacidil monohydrate | 85371-64-8 | sc-203198 sc-203198A | 10 mg 50 mg | $51.00 $95.00 | 6 | |
Pinacidil, a vasodilator, acts as a potassium channel opener, directly influencing MaxiKα channels. By enhancing potassium efflux, Pinacidil impacts cellular membrane potential, contributing to smooth muscle relaxation. | ||||||
Riociguat | 625115-55-1 | sc-476845 | 5 mg | $300.00 | ||
Riociguat, a stimulator of soluble guanylate cyclase (sGC), indirectly activates MaxiKα channels by elevating cGMP levels. The cGMP-dependent pathway modulates MaxiKα activity, influencing smooth muscle relaxation and cardiovascular functions. Riociguat provides insights into the complex interplay of signaling pathways regulating MaxiKα channels. | ||||||
Clotrimazole | 23593-75-1 | sc-3583 sc-3583A | 100 mg 1 g | $42.00 $57.00 | 6 | |
Clotrimazole, an antifungal agent, serves as a modulator of MaxiKα channels, directly influencing their activity. By altering potassium flux, Clotrimazole impacts cellular membrane potential, offering insights into the regulatory mechanisms of MaxiKα channels and their role in various cellular processes. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin, a flavonoid, indirectly activates MaxiKα channels by modulating cellular signaling pathways. Its influence on ion channel activity contributes to changes in cellular membrane potential, affecting processes regulated by MaxiKα, such as smooth muscle relaxation. Naringenin represents a natural compound with potential implications for MaxiKα modulation. | ||||||
Flupirtine Maleate | 75507-68-5 | sc-218512 | 10 mg | $103.00 | 1 | |
Flupirtine, a non-opioid analgesic, indirectly influences MaxiKα activation by modulating potassium channel activity. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $31.00 $102.00 | 1 | |
Dipyridamole, an antiplatelet agent, indirectly activates MaxiKα channels by modulating adenosine levels. Adenosine-mediated pathways influence MaxiKα activity, impacting smooth muscle relaxation and cardiovascular functions. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, a polyphenol, indirectly activates MaxiKα channels by influencing cellular signaling pathways. Its modulation of ion channel activity contributes to changes in cellular membrane potential, affecting processes regulated by MaxiKα, such as smooth muscle relaxation. Resveratrol represents a natural compound with potential implications for MaxiKα modulation. | ||||||
Niflumic acid | 4394-00-7 | sc-204820 | 5 g | $32.00 | 3 | |
Niflumic acid, a nonsteroidal anti-inflammatory drug (NSAID), indirectly activates MaxiKα channels by modulating cellular signaling pathways. Its influence on ion channel activity contributes to changes in cellular membrane potential, affecting processes regulated by MaxiKα, such as smooth muscle relaxation. | ||||||