MASGP-BP Activators
MASGP-BP activators make up a diverse class of chemical compounds that have the shared ability to induce expression of the membrane-associated secreted glycoprotein MASGP-BP. As a group, these activators represent different biological classes including steroids, signaling lipids, and endocrine disrupting chemicals. A key aspect of their activity in common is interaction with cellular signaling and transcriptional control pathways that regulate MASGP-BP gene transcription.
Many MASGP-BP activators are thought to work through nuclear receptor-mediated mechanisms, primarily the glucocorticoid, estrogen, androgen, progesterone, and other related steroid hormone receptors located within target cells. Binding of an activator to one of these receptors triggers a cascade of molecular events leading to increased recruitment of RNA polymerase and other transcription factors to genomic response elements present in regulatory regions of the MASGP-BP gene. This augments transcription and elevates MASGP-BP mRNA and protein production. In other cases, activators may exert their effect indirectly by interfering with cellular processes such as second messenger signaling, post-translational modifications, or general homeostasis pathways that secondarily impact nuclear receptor signaling networks and transcriptional controls linked to MASGP-BP gene regulation. Through complex combinations of direct receptor-mediated and indirect mechanisms, this assorted group of activators collectively functions to enhance MASGP-BP expression levels, representing an important area of focus for advancing understanding of the molecular biology and physiology involving this secreted glycoprotein.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that binds glucocorticoid receptors to induce transcription of certain genes including MASGP-BP, which is involved in cellular response to steroid hormones. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a non-selective beta adrenergic receptor agonist that could signal through beta receptor pathways to initiate a transcriptional response leading to increased MASGP-BP expression levels. | ||||||
Indomethacin | 53-86-1 | sc-200503 sc-200503A | 1 g 5 g | $29.00 $38.00 | 18 | |
Indomethacin is a nonsteroidal anti-inflammatory drug that inhibits prostaglandin production and may indirectly impact hormone responsive gene regulation including the MASGP-BP gene. | ||||||
Deoxycholic acid | 83-44-3 | sc-214865 sc-214865A sc-214865B | 5 g 25 g 1 kg | $37.00 $67.00 $941.00 | 4 | |
Deoxycholic acid sodium salt is a bile acid that could potentially impact lipid metabolism and membrane properties in a way that triggers signaling networks regulating MASGP-BP gene transcription. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A is an endocrine disrupting chemical that mimics estrogen activity and may induce MASGP-BP expression by interacting with estrogen receptors to modulate the activity of estrogen responsive elements in the MASGP-BP gene promoter region. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin is a flavonoid with weak estrogenic properties that could up-regulate MASGP-BP gene transcription through estrogen receptor pathways in a similar manner to xenoestrogens like bisphenol A. | ||||||
Ibuprofen | 15687-27-1 | sc-200534 sc-200534A | 1 g 5 g | $53.00 $88.00 | 6 | |
Ibuprofen is a nonsteroidal anti-inflammatory drug that inhibits prostaglandin synthesis and may indirectly cause changes in hormone responsive gene activity including increased expression of MASGP-BP. | ||||||
FCM Fixation buffer (10X) | sc-3622 | 10 ml @ 10X | $62.00 | 16 | ||
Formaldehyde can react with proteins and nucleotides to potentially alter transcription factor binding and indirectly modulate transcriptional regulation of the MASGP-BP gene. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $61.00 $110.00 | 21 | |
Chlorpromazine is a phenothiazine derivative with antagonist activity at dopamine receptors and could induce MASGP-BP expression levels through impacting downstream dopaminergic signaling pathways involved in transcriptional controls. | ||||||
(±)-Menthol | 89-78-1 | sc-250299 sc-250299A | 100 g 250 g | $39.00 $68.00 | ||
(±)-Menthol is a monocyclic terpene alcohol that may be able to trigger intracellular signaling pathways leading to altered transcriptional activity of the MASGP-BP gene. | ||||||