MAGE-G1 Inhibitors
MAGE-G1 inhibitors belong to a specialized class of chemical compounds designed to target the Melanoma-Associated Antigen G1 (MAGE-G1) protein. MAGE-G1 is a member of the MAGE family of proteins, which play a crucial role in various cellular processes. The inhibitors designed for MAGE-G1 function by specifically binding to the protein and modulating its activity, thereby influencing downstream cellular pathways. These inhibitors are meticulously crafted to interfere with the abnormal expression or function of MAGE-G1, which is often associated with the development and progression of certain types of cancer.
The structural design of MAGE-G1 inhibitors involves careful consideration of the protein's molecular architecture and its interactions within cellular mechanisms. Researchers focus on creating compounds with high selectivity and affinity for MAGE-G1, aiming to disrupt its biological functions without causing unintended effects on other cellular components. As part of ongoing advancements in cancer research, the exploration of MAGE-G1 inhibitors represents a targeted approach towards understanding and potentially manipulating the intricate molecular networks that contribute to tumorigenesis. The development and study of MAGE-G1 inhibitors contribute to the broader field of cancer biology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. MAGE-G1, being a cancer/testis antigen, may have transcriptional regulation that is epigenetically modulated. By inhibiting histone deacetylases, Trichostatin A can alter chromatin structure and potentially downregulate MAGE-G1 expression through increased acetylation, leading to a more open chromatin state and allowing for the binding of transcription repressors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. By inhibiting DNA methylation, it may lead to the re-expression of silenced genes that could act as tumor suppressors, which in turn could downregulate the expression of tumor-associated antigens like MAGE-G1 by altering the tumor microenvironment and inducing cellular differentiation or apoptosis. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
All-trans Retinoic Acid induces cell differentiation and is known to influence the expression of various genes. It might decrease the expression of MAGE-G1 by promoting the differentiation of cells in which MAGE-G1 is typically expressed, such as undifferentiated cancer cells. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib is a proteasome inhibitor. By inhibiting the proteasome, it may cause an accumulation of regulatory proteins that could lead to cell cycle arrest or apoptosis in cancer cells, which might result in downregulation of cancer/testis antigens such as MAGE-G1 in the affected cells. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can bind to and inhibit the proteasome, similarly to Bortezomib. Proteasome inhibition could lead to the accumulation of misfolded proteins and subsequent cell stress or death, which may decrease the expression of proteins like MAGE-G1 due to cell death or stress responses. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is another histone deacetylase inhibitor like Trichostatin A. It may downregulate MAGE-G1 by altering chromatin accessibility and encouraging the transcription of genes that repress the expression of cancer/testis antigens like MAGE-G1. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Like 5-Azacytidine, Decitabine is a DNA methyltransferase inhibitor. It may lead to the reactivation of tumor suppressor genes that could counteract the expression of MAGE-G1 by altering the epigenetic state of cancer cells and promoting apoptosis or differentiation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and proliferation. By inhibiting this pathway, it could indirectly lead to a decrease in MAGE-G1 expression by reducing the overall rate of cell growth and protein synthesis in cells where MAGE-G1 is typically upregulated, such as in certain cancer cells. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 disrupts the interaction between p53 and its negative regulator MDM2. Stabilization of p53 can lead to cell cycle arrest or apoptosis, potentially reducing the expression of MAGE-G1 in p53-responsive cells. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor. By blocking the degradation pathway of proteins, it can lead to cell stress and potential cell death, which may lower MAGE-G1 levels due to decreased viability of cells expressing this protein. | ||||||