Date published: 2026-5-30

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MafK Inhibitors

MafK, a member of the Maf protein family, is a transcription factor characterized by a basic leucine zipper domain that facilitates its dimerization and subsequent binding to DNA. MafK can form heterodimers with other proteins, notably with members of the Cap'n'collar (CNC) family of bZIP proteins, such as Nrf2. These complexes play a crucial role in the regulation of gene expression related to oxidative stress response and detoxification pathways. MafK is also implicated in developmental and physiological processes, including the regulation of erythroid differentiation and the maintenance of cellular homeostasis. The expression of MafK itself is tightly controlled within the cell, as it is central to the regulation of various genes, and its dysregulation could lead to disturbances in cellular function. A number of chemical compounds have been identified that could potentially inhibit the expression of MafK, each interacting with different cellular components and pathways. For example, compounds like curcumin and resveratrol are known to interact with transcription factors and may lead to the downregulation of MafK expression by altering the activity of these proteins. Sulforaphane and similar compounds may decrease MafK expression by changing the dynamic equilibrium of the Nrf2 pathway, thereby affecting the transcriptional regulation of detoxification genes. Other compounds, such as quercetin and epigallocatechin gallate, might inhibit MafK expression by affecting the phosphorylation status of transcriptional coactivators or by changing the methylation status of the gene's promoter. Some substances, including genistein and kaempferol, could potentially hinder the signaling pathways upstream of the MafK gene or directly affect the chromatin structure associated with the MafK gene, leading to reduced expression. It's important to note that these interactions are complex and the exact mechanism of inhibition regarding MafK expression would require comprehensive experimental validation.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin may downregulate MafK expression by inhibiting the activation of specific transcription factors responsible for MafK gene transcription or by altering the cellular redox state which can have a downstream effect on gene expression profiles.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol could decrease MafK expression through its ability to inhibit kinase signaling pathways that are upstream of the transcriptional machinery governing the MafK gene, possibly leading to reduced transcriptional initiation.

D,L-Sulforaphane

4478-93-7sc-207495A
sc-207495B
sc-207495C
sc-207495
sc-207495E
sc-207495D
5 mg
10 mg
25 mg
1 g
10 g
250 mg
$153.00
$292.00
$489.00
$1325.00
$8465.00
$933.00
22
(1)

DL-Sulforaphane might decrease the expression of MafK by shifting the Nrf2 pathway's equilibrium, leading to an altered transcriptional response that could include the suppression of MafK gene activity.

Quercetin

117-39-5sc-206089
sc-206089A
sc-206089E
sc-206089C
sc-206089D
sc-206089B
100 mg
500 mg
100 g
250 g
1 kg
25 g
$11.00
$17.00
$110.00
$250.00
$936.00
$50.00
33
(2)

Quercetin may reduce MafK expression by hindering the phosphorylation status of transcriptional coactivators involved in MafK gene expression, leading to a decrease in their binding affinity to the MafK promoter.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

Epigallocatechin Gallate could downregulate MafK expression by inhibiting the DNA-binding activity of certain transcription factors or by altering the methylation status of the MafK gene promoter, thus reducing its transcriptional activity.

Genistein

446-72-0sc-3515
sc-3515A
sc-3515B
sc-3515C
sc-3515D
sc-3515E
sc-3515F
100 mg
500 mg
1 g
5 g
10 g
25 g
100 g
$45.00
$164.00
$200.00
$402.00
$575.00
$981.00
$2031.00
46
(1)

Genistein has the potential to decrease MafK expression by inhibiting tyrosine kinases that are involved in the signaling pathways controlling the transcription of the MafK gene, leading to a reduction in gene expression.

Kaempferol

520-18-3sc-202679
sc-202679A
sc-202679B
25 mg
100 mg
1 g
$99.00
$216.00
$510.00
11
(1)

Kaempferol might inhibit MafK expression by directly inhibiting the histone acetylation on the MafK promoter, which is crucial for the transcriptional assembly and initiation of gene transcription.

Indole-3-carbinol

700-06-1sc-202662
sc-202662A
sc-202662B
sc-202662C
sc-202662D
1 g
5 g
100 g
250 g
1 kg
$39.00
$61.00
$146.00
$312.00
$1032.00
5
(1)

Indole-3-carbinol may reduce MafK expression by decreasing the nuclear translocation of transcription factors that are essential for the expression of the MafK gene, thereby limiting their availability at the gene promoter.

3,3′-Diindolylmethane

1968-05-4sc-204624
sc-204624A
sc-204624B
sc-204624C
sc-204624D
sc-204624E
100 mg
500 mg
5 g
10 g
50 g
1 g
$37.00
$65.00
$89.00
$421.00
$681.00
$66.00
8
(1)

3,3'-Diindolylmethane could inhibit MafK expression by altering the expression of miRNAs that target the mRNA of the MafK gene, leading to increased mRNA degradation and decreased translation.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid might downregulate MafK expression by activating retinoic acid receptors that repress the transcription of the MafK gene through competitive binding to shared co-regulatory proteins.