M13 Major Coat Protein Activators
The M13 major coat protein (MCP) is a fundamental component of the filamentous bacteriophage M13, which infects Escherichia coli bacteria. As a structural protein, the primary function of the M13 MCP is to form the outer shell, or capsid, of the viral particle. This capsid structure serves to encapsulate and protect the single-stranded DNA genome of the virus during its replication and transmission. Additionally, the MCP is essential for the assembly and maturation of the viral particles, ensuring the efficient production and release of infectious virions from the host bacterial cell. Through interactions with other viral proteins and host factors, the MCP coordinates the assembly process, guiding the formation of the filamentous viral particles.
Activation of the M13 major coat protein primarily occurs through the coordinated processes of viral genome replication and protein synthesis within the host bacterial cell. Upon infection, the viral genome is introduced into the host cell, where it undergoes replication to generate multiple copies of the viral DNA. Concurrently, the host cellular machinery is hijacked to transcribe and translate viral genes, including those encoding the MCP. The newly synthesized MCP molecules are then processed and assembled into the capsid structure, driven by specific protein-protein interactions and self-assembly properties inherent to the MCP. Additionally, post-translational modifications or chaperone-mediated folding may contribute to the activation of the MCP and its incorporation into the mature viral particles. Overall, activation of the M13 MCP is intricately linked to the viral life cycle and is governed by a series of coordinated events that culminate in the successful assembly and release of infectious viral particles.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates M13 Major Coat Protein by directly stimulating adenylate cyclase, leading to an increase in intracellular cAMP levels. Elevated cAMP activates protein kinase A (PKA), which phosphorylates and activates M13 activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187, a calcium ionophore, activates M13 indirectly by increasing intracellular calcium levels. Elevated calcium levels influence downstream signaling pathways, such as PKA and CAMKII, leading to the activation of M13 Major Coat Protein. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates M13 by modulating the SIRT1/AMPK pathway. It enhances SIRT1 activity, leading to deacetylation and activation of AMPK. Activated AMPK subsequently influences signaling pathways that converge on M13, resulting in its activation. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Bay K 8644, an L-type calcium channel activator, increases intracellular calcium levels, influencing calcium-dependent signaling pathways. This indirectly activates M13 Major Coat Protein by modulating downstream effectors linked to M13 activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX activates M13 by inhibiting phosphodiesterase, leading to an accumulation of intracellular cAMP. Elevated cAMP levels activate PKA, initiating a cascade of events that culminate in the activation of M13 Major Coat Protein. | ||||||
(−)Epicatechin | 490-46-0 | sc-205672 sc-205672A | 1 mg 5 mg | $50.00 $135.00 | ||
Epicatechin activates M13 by promoting the SIRT1/AMPK pathway. It enhances SIRT1 activity, leading to AMPK activation, which in turn influences signaling pathways converging on M13, ultimately resulting in its activation and cellular functions. | ||||||
1-Phenylbiguanide | 102-02-3 | sc-222728 | 25 g | $419.00 | ||
1-Phenylbiguanide activates M13 indirectly by stimulating serotonin receptors and initiating downstream signaling cascades. The activation of these pathways influences M13 Major Coat Protein, contributing to its activation and functional modulation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 activates M13 by inhibiting NF-κB signaling. Suppression of NF-κB activity by Bay 11-7082 influences downstream pathways linked to M13, leading to its activation and modulation of cellular functions. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine activates M13 indirectly by modulating DNA methylation patterns. Demethylation induced by 5-Azacytidine influences gene expression, including genes related to M13 Major Coat Protein, leading to its activation and functional modulation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP, a cell-permeable analog of cAMP, directly activates M13 by mimicking the effects of elevated intracellular cAMP. It stimulates PKA, initiating a signaling cascade that results in the activation and functional modulation of M13 Major Coat Protein. | ||||||