LYRM2 Inhibitors
Chemical inhibitors of LYRM2 can disrupt the mitochondrial electron transport chain (ETC) at various points, leading to an indirect inhibition of the protein's function. Rotenone and Piericidin A target mitochondrial complex I, where LYRM2 is involved in the assembly of the ETC complexes. By inhibiting complex I, these chemicals impede the initial stage of the electron transport chain, leading to a reduced production of ATP, which is essential for the energy-dependent assembly processes that LYRM2 supports. Similarly, Antimycin A and Stigmatellin inhibit complex III, another key point in the ETC. Antimycin A prevents the transfer of electrons from ubiquinol to cytochrome c, while Stigmatellin disrupts the ubiquinol oxidation site, both resulting in a breakdown of the proton gradient necessary for ATP synthesis. With ATP production compromised, the function of LYRM2 is indirectly inhibited due to the lack of energy required for its role in the assembly of the ETC.
Carboxin, Thenoyltrifluoroacetone (TTFA), Atpenin A5, and Malonate exert their inhibitory effects by targeting complex II. Carboxin and Atpenin A5 directly influence the succinate dehydrogenase portion of complex II, while TTFA and Malonate disrupt its function by impeding the electron transfer process. As a result, the complete assembly and function of the mitochondrial complexes, where LYRM2 is involved, are hampered. On the other end, Sodium azide and Cyanide inhibit complex IV by targeting cytochrome c oxidase, leading to a halt in the electron transport chain and causing a drop in ATP production. Oligomycin intervenes at the final step of the ETC by inhibiting ATP synthase (complex V). This inhibition blocks the synthesis of ATP, which drives the assembly and maintenance of mitochondrial complexes. In essence, these chemical inhibitors, by disrupting various components of the ETC, lead to a functional inhibition of LYRM2 by depriving it of the necessary energy and components required for proper mitochondrial function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $254.00 | 41 | |
Rotenone inhibits mitochondrial complex I, which is a necessary component for ATP synthesis. LYRM2 is involved in the assembly of mitochondrial respiratory chain complexes; by compromising ATP synthesis, rotenone reduces the energy supply required for the assembly process, thereby functionally inhibiting LYRM2. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $54.00 $62.00 $1642.00 $4600.00 | 51 | |
Antimycin A inhibits mitochondrial complex III, which is upstream of complex I and II where LYRM2 is involved. The inhibition of complex III disrupts the electron transport chain, leading to a reduced production of ATP and thus inhibiting the energy-dependent processes in which LYRM2 is involved. | ||||||
Carboxine | 5234-68-4 | sc-234286 | 250 mg | $21.00 | 1 | |
Carboxin specifically targets and inhibits succinate dehydrogenase (complex II) in mitochondria. As LYRM2 is engaged in the formation and stabilization of mitochondrial complexes, inhibition of complex II can impede its function, indirectly inhibiting LYRM2. | ||||||
2-Thenoyltrifluoroacetone | 326-91-0 | sc-251801 | 5 g | $36.00 | 1 | |
Thenoyltrifluoroacetone (TTFA) is an inhibitor of mitochondrial complex II. By disrupting the function of complex II, TTFA indirectly inhibits LYRM2 by impeding the assembly and activity of the respiratory chain complexes that LYRM2 is known to support. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $42.00 $152.00 $385.00 $845.00 $88.00 | 8 | |
Sodium azide inhibits cytochrome c oxidase in complex IV of the mitochondrial electron transport chain. By inhibiting this complex, the overall function of the electron transport chain is compromised, which indirectly inhibits LYRM2's role in the assembly of the mitochondrial complexes. | ||||||
Oligomycin | 1404-19-9 | sc-203342 sc-203342C | 10 mg 1 g | $146.00 $12250.00 | 18 | |
Oligomycin inhibits the mitochondrial ATP synthase (complex V). This inhibition leads to a reduction in ATP production, which is necessary for the assembly of mitochondrial respiratory complexes, thereby functionally inhibiting LYRM2. | ||||||
Piericidin A | 2738-64-9 | sc-202287 | 2 mg | $285.00 | 24 | |
Piericidin A is an inhibitor of mitochondrial complex I. By inhibiting complex I, piericidin A interferes with the normal function of the electron transport chain, in which LYRM2 plays a critical role, thereby functionally inhibiting LYRM2. | ||||||
Atpenin A5 | 119509-24-9 | sc-202475 sc-202475A sc-202475B sc-202475C | 250 µg 1 mg 10 mg 50 mg | $140.00 $424.00 $2652.00 $12240.00 | 17 | |
Atpenin A5 specifically inhibits complex II of the mitochondrial electron transport chain. With complex II inhibited, the proper functioning and assembly of mitochondrial complexes that LYRM2 is involved in are impeded, leading to its functional inhibition. | ||||||