Ly-49H Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A inhibits calcineurin, which is essential for the activation of T-cells. By inhibiting calcineurin, Cyclosporin A indirectly inhibits the activity of Ly-49H, which is involved in the immune response, as it may regulate natural killer (NK) cell function in response to activating signals. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a Src family kinase inhibitor. Ly-49H is associated with signaling pathways involving Src family kinases. Inhibition of these kinases by Dasatinib can lead to the functional inhibition of Ly-49H by disrupting its associated signaling pathways essential for its function in NK cells. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is another inhibitor of Src family kinases. By inhibiting Src family kinases, PP2 disrupts signal transduction pathways that are necessary for the functional activation of Ly-49H in NK cells, resulting in the inhibition of its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor. Since PI3K signaling is crucial for NK cell activation and function, inhibition of PI3K by LY294002 can lead to functional inhibition of Ly-49H by impairing the signaling pathways that facilitate its role in NK cell cytotoxicity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is also a PI3K inhibitor and functions similarly to LY294002. It disrupts the PI3K-dependent signaling pathways that are necessary for the activation and function of Ly-49H in NK cells, thus functionally inhibiting Ly-49H. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of mitogen-activated protein kinase (MAPK) kinase, which is upstream of extracellular signal-regulated kinase (ERK). ERK is implicated in NK cell regulatory functions, and by inhibiting MAPK/ERK signaling, PD 98059 can inhibit the function of Ly-49H. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is another MAPK/ERK inhibitor, which can lead to the functional inhibition of Ly-49H by blocking the MAPK/ERK signaling pathway that contributes to the activation and function of Ly-49H in NK cells. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor, which plays a role in NK cell activation. Inhibition of p38 MAP kinase by SB203580 can impair the signaling pathways that are necessary for the activation and hence the function of Ly-49H. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which is involved in the regulation of immune responses. By inhibiting JNK, SP600125 can disrupt signaling pathways that contribute to the functional activity of Ly-49H in NK cells. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
BAY 11-7082 inhibits NF-kB activation by blocking phosphorylation of IκBα. Since NF-kB is a transcription factor that regulates the expression of genes involved in immune responses, its inhibition can result in the functional inhibition of Ly-49H by impairing necessary immune signaling pathways. | ||||||