Loricrin Inhibitors

In the chemical class of Loricrin Inhibitors, each compound presents a unique mechanism through which it can reduce loricrin expression or impair its function in the skin. Compounds like Hydrocortisone and Benzoyl Peroxide can, through prolonged or excessive use, impair the skin's natural barrier function and negatively impact loricrin levels. Similarly, Ethanol and Sodium Lauryl Sulfate, known for their drying and detergent properties, respectively, can strip the skin of its natural oils, disrupting the skin barrier and reducing loricrin expression.

Tretinoin, although beneficial in regulated amounts, can lead to skin irritation when used in high concentrations, possibly affecting loricrin expression. Coal Tar and Thimerosal, due to their irritating and toxic properties, can disrupt normal skin cell function, leading to reduced expression of loricrin. Chemicals like Diethyl Phthalate and Methylparaben, found in certain cosmetics, may interfere with the skin's barrier integrity, impacting loricrin. Quaternium-15, as a formaldehyde-releasing agent, can irritate the skin and affect its barrier function, while Isopropyl Alcohol's drying effect might similarly decrease loricrin expression. Lastly, Lead Acetate represents heavy metal exposure that can be detrimental to skin cells and barrier function, reducing loricrin levels.