LONRF3 Activators
LONRF3 activators exert their effects through a variety of cellular mechanisms, thereby enhancing the protein's functional activity, which is crucial for maintaining protein homeostasis within the cell. Notably, certain activators increase intracellular second messengers like cAMP, which in turn activates downstream kinases such as protein kinase A. This cascade of events can lead to an upregulation of the ubiquitin-proteasome system, where LONRF3 plays a significant role in protein degradation. Additionally, some compounds can induce oxidative stress by inhibiting specific enzymes or generating reactive oxygen species. The resulting accumulation of misfolded or damaged proteins necessitates the intervention of protein quality control mechanisms, wherein LONRF3's proteolytic activity is crucial for mitigating the effects of cellular stress and restoring proteostasis.
Furthermore, the induction of autophagy by other activators links to the ubiquitin-proteasome pathway, potentially leading to an increase in LONRF3 activity to manage the autophagic degradation of proteins. Inhibitors of the proteasome itself result in an accumulation of ubiquitinated proteins, which can indirectly signal the need for heightened activity of LONRF3 to compensate for the impaired degradation capacity. Other activators disrupt intracellular calcium homeostasis or inhibit specific kinases, triggering stress responses such as the unfolded protein response, which can then enhance LONRF3 activity to deal with an increased load of unfolded or misfolded proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
By elevating intracellular cAMP levels, Forskolin activates protein kinase A (PKA). PKA phosphorylation can enhance the ubiquitin-proteasome system, which could potentially increase the activity of LONRF3 as it is involved in protein degradation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in cell signaling and could enhance the ubiquitination process. LONRF3, being part of the ubiquitin-proteasome system, might have increased activity due to elevated ubiquitination. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby potentially activating calcium-dependent proteases. This could indirectly activate LONRF3 by increasing the demand for proteasomal degradation of misfolded proteins. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits the proteasome, leading to the accumulation of ubiquitinated proteins. This could indirectly activate LONRF3 by upregulating its activity to compensate for proteasome inhibition. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin inhibits thioredoxin reductase, leading to oxidative stress. The resulting increased misfolded or damaged proteins could stimulate LONRF3 activity to maintain cellular proteostasis. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $48.00 $179.00 $310.00 $96.00 | 3 | |
Sodium selenite enhances oxidative stress, potentially increasing the level of damaged proteins, which may activate LONRF3 due to its role in protein quality control. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Spermidine induces autophagy which is closely linked with the ubiquitin-proteasome system where LONRF3 functions, potentially leading to an increase in LONRF3 activity to handle the autophagic turnover of proteins. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $33.00 $102.00 | 87 | |
Salubrinal inhibits dephosphorylation of eIF2α, resulting in an accumulation of misfolded proteins and an enhanced demand for proteasomal degradation, possibly activating LONRF3 in the process. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis, which can lead to endoplasmic reticulum stress and upregulation of proteasome activity, potentially increasing the activity of LONRF3 as part of the unfolded protein response. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
As a proteasome inhibitor, Bortezomib causes the accumulation of ubiquitinated proteins, which could indirectly activate LONRF3 to help clear the backlog of substrates. | ||||||