LOC729599 Inhibitors

The inhibition of PI3K by Wortmannin and LY294002 can lead to the suppression of the PI3K/Akt signaling pathway, a crucial pathway for numerous cellular functions. This suppression can result in the alteration of LOC729599's activity if it is regulated by PI3K/Akt signaling. The chemical class further includes inhibitors of other pathways like mTOR, MEK, p38 MAPK, JNK, Src family kinases, and Aurora kinase, as well as EGFR tyrosine kinase and glycolysis.

Rapamycin's action on mTOR, PD98059 and U0126's targeting of MEK, and the impact of SB203580 and SP600125 on p38 MAPK and JNK, respectively, all contribute to the modulation of signaling pathways that can affect the activity of LOC729599. PP2 and Dasatinib disrupt Src kinase signaling, while ZM-447439 interferes with cell cycle-related kinases. Gefitinib's inhibition of EGFR tyrosine kinase and the action of 2-Deoxy-D-glucose on glycolysis present additional mechanisms by which the activity of LOC729599 can be influenced.