LOC729005 Inhibitors
LOC729005 inhibitors Wortmannin and LY294002 target PI3K, a pivotal kinase in cell signaling, potentially affecting proteins regulated by this pathway. Their binding impedes PI3K's kinase activity, thereby influencing downstream signaling events. Rapamycin, engaging with mTOR, acts to dampen the mTOR pathway, which is integral to protein synthesis and cell proliferation. This interaction can lead to a cascade of effects on proteins that are regulated by mTOR signaling. Compounds like SB203580 and PD98059 exhibit selectivity towards MAP kinases, pivotal in cellular responses to extracellular stimuli. SB203580 inhibits p38 MAP kinase, while PD98059 targets MEK, an upstream regulator of MAP kinases, thereby modulating the phosphorylation state and activity of proteins downstream of these kinases. SP600125 and U0126, by inhibiting JNK and MEK1/2 respectively, alter the signaling trajectory of their respective pathways, potentially affecting proteins that are responsive to stress and mitogenic signals controlled by these kinases.
Trichostatin A and 5-Azacytidine mediate changes in gene expression by modifying chromatin structure and DNA methylation status, respectively. Trichostatin A inhibits HDACs, affecting histone acetylation and thus gene transcription, which in turn can influence protein expression and function. 5-Azacytidine, by incorporating into nucleic acids, induces DNA hypomethylation, leading to changes in gene expression profiles that can affect protein regulation. Brefeldin A, Cyclosporin A, and Thapsigargin interact with distinct cellular targets involved in protein processing and intracellular signaling. Brefeldin A disrupts protein transport by inhibiting Golgi function, which can affect the localization and function of proteins reliant on the secretory pathway. Cyclosporin A binds to calcineurin, impacting T-cell activation and subsequent protein activities within the immune signaling cascade. Thapsigargin, by inhibiting SERCA pumps, elevates cytosolic calcium levels, thereby affecting proteins that are sensitive to calcium signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a steroidal metabolite of fungi and acts as a potent inhibitor of phosphoinositide 3-kinases (PI3K), which can regulate a variety of proteins involved in cell growth, proliferation, and survival. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a synthetic molecule that functions as a PI3K inhibitor, similar to wortmannin, but is more stable and less toxic, thus affecting related protein activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is a macrolide compound that can inhibit mTOR (mammalian target of rapamycin), a key protein kinase that can control protein synthesis and cell proliferation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a synthetic compound that acts as an inhibitor of p38 MAP kinase, which is involved in cellular responses to stress and inflammation and can modulate protein activities. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a synthetic compound that inhibits MEK, which is upstream of the MAP kinase pathway and can regulate various proteins by influencing gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), affecting cellular processes such as apoptosis and can alter the function of numerous proteins. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a hydroxamic acid derivative that inhibits histone deacetylases (HDAC), affecting chromatin structure and gene transcription, which can modulate protein function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a nucleoside analog of cytidine that can incorporate into RNA and DNA, leading to hypomethylation of DNA and can alter gene expression affecting protein regulation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is a lactone antibiotic that disrupts the function of the Golgi apparatus, leading to a blockade in protein transport and potentially affecting protein function. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporin A is a cyclic peptide that can inhibit calcineurin, leading to altered T-cell activation and can affect the activity of various proteins in the immune signal transduction pathway. | ||||||