LOC728867 Activators

Forskolin and IBMX are known to elevate the levels of cyclic nucleotides within the cell, which activate PKA and PKG, respectively. These kinases can phosphorylate a wide range of substrates, resulting in changes to protein activity. PMA and Ionomycin are classic activators of PKC and calcium-dependent proteins, leading to multiple downstream effects on protein function. LY294002 and U0126 provide examples of small molecules that inhibit key kinases within the PI3K/AKT and MAPK/ERK pathways. The inhibition of these kinases can lead to compensatory activation of proteins within these or alternate pathways.

Similarly, SB203580 and SP600125 modulate the activity of p38 MAPK and JNK, respectively, influencing a variety of proteins regulated by these kinases. Y-27632, DAPT, and Rapamycin each target specific components of major signaling pathways – ROCK, Notch, and mTOR, respectively – and can result in the activation of proteins through intricate feedback loops and regulatory mechanisms. Zinc chloride serves as an example of a simple inorganic compound that can have profound effects on protein activity through its role as a cofactor for metalloproteins.