The protein "coiled-coil domain containing 188" (CCDC188) is a member of the CCDC family of proteins, which are named for the presence of coiled-coil domains within their structure. These domains are characterized by a heptad repeat pattern of amino acids that form an alpha-helical structure, with two or more of these helices intertwining to create a stable coiled-coil.
CCDC188, like other proteins in this family, likely participates in a variety of cellular processes involving protein-protein interactions. The coiled-coil motif is known to facilitate the assembly of multi-protein complexes, which are crucial in diverse cellular functions such as intracellular trafficking, cell division, signal transduction, and the regulation of gene expression.While the specific functions of CCDC188 may not be fully characterized, its structural features suggest a role in maintaining the architecture of certain protein complexes or scaffolds, potentially impacting cellular organization and communication. The coiled-coil domain is often involved in the formation of cytoskeletal structures, vesicle transport, and the organization of the nuclear envelope, among other functions.
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