LHFPL3 Activators
Phosphatidylinositol 4,5-bisphosphate (PIP2) and cholesterol are two critical components of cell membranes that can influence the activity of LHFPL3, a membrane protein. PIP2 serves as a substrate for enzyme-catalyzed reactions leading to the formation of second messengers, which are central to intracellular signaling cascades. The hydrolysis of PIP2 by phospholipase C (PLC) yields diacylglycerol (DAG) and inositol triphosphate (IP3), both of which could modify the membrane environment and subsequently enhance LHFPL3's activity by altering its conformation or interaction with other proteins. Cholesterol, on the other hand, affects membrane fluidity and is integral to the formation of lipid rafts. The presence of cholesterol within these domains can enhance the functional activity of LHFPL3 by promoting its stable integration into these microdomains, facilitating its role in signal transduction.
Compounds such as forskolin, sphingosine-1-phosphate (S1P), arachidonic acid, and nicotinamide adenine dinucleotide (NAD+) can all influence cellular signaling pathways that indirectly enhance the functional activity of LHFPL3. Forskolin raises intracellular cyclic AMP (cAMP) levels, leading to activation of protein kinase A (PKA), which could phosphorylate LHFPL3 or modulate its activity through changes in the cellular cAMP landscape. S1P is a bioactive lipid that, through its receptors or secondary signaling events, could induce modifications in cellular processes that indirectly enhance LHFPL3 activity. Arachidonic acid is a precursor to eicosanoids, which are involved in diverse signaling pathways and could modify the cellular context in which LHFPL3 operates, leading to enhanced activity. NAD+, through its role in redox reactions or as a substrate for ADP-ribosylation, could create a favorable metabolic environment or influence post-translational modifications that enhance the activity of LHFPL3. Curcumin and EGCG are bioactive compounds with anti-inflammatory and antioxidant properties, respectively, and can modulate various signaling pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
It is plausible that cholesterol levels can modulate the membrane environment of LHFPL3, potentially enhancing its activity by stabilizing the protein within lipid rafts, which are cholesterol-rich microdomains where signal transduction often occurs. This stabilization could lead to an increased functional activity of LHFPL3 due to improved interactions with other proteins within these microdomains. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels within cells. Elevated cAMP can activate protein kinase A (PKA), which can phosphorylate various targets including membrane proteins. LHFPL3, when phosphorylated by PKA or influenced by changes in cAMP levels, could exhibit an increased functional activity due to conformational changes or altered interactions with other membrane proteins or lipids. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate (S1P) is a lipid signaling molecule that can influence a broad range of cellular processes including growth, survival, and migration. It can also modulate the activity of various membrane proteins. | ||||||
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a polyunsaturated fatty acid that serves as a precursor for the synthesis of eicosanoids, which are signaling molecules involved in inflammation and other cellular processes. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NAD+ is a coenzyme found in all living cells and is involved in redox reactions. It can also serve as a substrate for ADP-ribosylation, which can modify protein function. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a bioactive compound found in turmeric with known anti-inflammatory properties. It can modulate various signaling pathways, including those involving NF-κB, and can affect the activity of numerous proteins. By altering inflammatory signaling pathways, curcumin could indirectly enhance the functional activity of LHFPL3 by reducing a pro-inflammatory environment that might otherwise suppress its activity, or by influencing the protein's interaction with other signaling molecules. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is the most abundant catechin in tea and has antioxidant properties. It can modulate several signaling pathways and has been shown to affect the activity of a variety of proteins. | ||||||