LATS2 Activators

LATS2 Activators encompass a group of compounds or conditions that can directly or indirectly enhance the activity or expression of LATS2 (Large Tumor Suppressor Kinase 2). LATS2 is a central kinase in the Hippo signaling pathway, a crucial pathway involved in organ size control, tissue regeneration, and tumorigenesis suppression. The activation of LATS2, therefore, influences cellular proliferation, apoptosis, and other significant cellular events.

The precise mechanisms through which LATS2 is activated can be multifaceted. For some molecules, the activation might be direct, through a binding event or modification that enhances the kinase activity of LATS2. However, for many potential activators, the mechanism is indirect and might involve modulating upstream regulators or associated pathways that, in turn, impact LATS2 function. For instance, certain cell stressors or alterations in cellular nutrient status might activate the Hippo pathway, subsequently influencing LATS2 activity. Additionally, molecules that modulate post-translational modifications, such as phosphorylation events critical to LATS2 function, could indirectly serve as activators.