Latrophilin-2 Activators

Latrophilin-2, also known as ADGRL2, is a member of the G-protein coupled receptor family. Latrophilin-2 Activators comprises compounds that can influence its activity, either directly or through associated cellular pathways.

Among the prominent members of this class is cAMP, a secondary messenger pivotal in numerous cellular functions. Elevated cAMP levels can enhance ADGRL2-associated pathways, with Forskolin serving as an agent capable of inducing this elevation. Neurotransmitters such as Epinephrine and Norepinephrine, by modulating the activity of G-protein coupled receptors, can similarly exert influence on ADGRL2-related pathways. Isoproterenol, a synthetic agonist of beta-adrenergic receptors, presents another mechanism of indirect modulation by affecting these receptors. On the other hand, Acetylcholine's interactions with muscarinic receptors offer yet another avenue for influencing GPCRs activity connected to ADGRL2. Furthermore, extracellular signals like ATP and UTP, through their action on purinergic receptors, can impact pathways that may intersect with ADGRL2 activity. The role of GTPγS, a non-hydrolyzable GTP analogue, is of significance as it can activate G-proteins that in turn affect GPCRs. Lastly, PGE2, by engaging with EP receptors, and SQ 22,536, an adenylate cyclase inhibitor, alongside 8-Br-cAMP, a membrane-permeable cAMP analog, represent diverse mechanisms by which cellular pathways relevant to ADGRL2 can be modulated.