LAP1B Activators
Chemical activators of LAP1B are anticipated to work by stabilizing the nuclear envelope or by modulating cellular processes that ensure the proper function of nuclear envelope-associated proteins. Retinoic acid can affect gene expression and nuclear structure, potentially facilitating LAP1B activity. Forskolin, by increasing intracellular cAMP, can potentiate processes that stabilize cellular compartments, including the nuclear envelope, thereby potentially supporting LAP1B activity. PMA activates PKC, which is known to phosphorylate various substrates that could be involved in maintaining the nuclear envelope structure.
Compounds such as EGCG and spermidine have broad effects on cellular homeostasis, which include supporting nuclear function. Sodium phenylbutyrate acts as a chemical chaperone, which could enhance the functional state of LAP1B through improved protein folding. Geldanamycin, by activating HSF1, may upregulate chaperones that assist in the correct folding of nuclear envelope proteins. Beta-Lapachone, melatonin, lithium chloride, resveratrol, and ascorbic acid have roles in redox balance, gene expression modulation, and stress response pathways that maintain cellular integrity, which is vital for the functionality of nuclear envelope proteins such as LAP1B.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
A metabolite of vitamin A that influences gene expression and nuclear receptor signaling, potentially supporting LAP1B activity related to nuclear structure. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator that increases cAMP levels, which may promote cellular processes and indirectly enhance LAP1B activity associated with the nucleus. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates protein kinase C (PKC) which can influence nuclear envelope dynamics through phosphorylation events, potentially supporting LAP1B activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
A polyphenol from green tea that has been found to have various cellular effects, which may include supporting the function of nuclear envelope-associated proteins like LAP1B. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $75.00 $163.00 $622.00 $4906.00 $32140.00 | 43 | |
A chemical chaperone that may enhance the folding and function of proteins associated with the nuclear envelope, potentially aiding LAP1B function. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Hsp90 inhibitor that leads to the activation of heat shock factor 1 (HSF1) and could promote proper folding and function of nuclear envelope proteins, indirectly supporting LAP1B activity. | ||||||
Spermidine | 124-20-9 | sc-215900 sc-215900B sc-215900A | 1 g 25 g 5 g | $56.00 $595.00 $173.00 | ||
Polyamine known to induce autophagy and can contribute to cellular homeostasis, possibly supporting nuclear envelope integrity and LAP1B function. | ||||||
β-Lapachone | 4707-32-8 | sc-200875 sc-200875A | 5 mg 25 mg | $110.00 $450.00 | 8 | |
Influences cellular redox states and may affect nuclear dynamics, potentially supporting LAP1B activity. | ||||||
Melatonin | 73-31-4 | sc-207848 sc-207848A sc-207848B sc-207848C sc-207848D sc-207848E | 1 g 5 g 25 g 100 g 250 g 1 kg | $64.00 $72.00 $214.00 $683.00 $1173.00 $3504.00 | 16 | |
A hormone that can act as an antioxidant and supports cellular health, possibly maintaining nuclear envelope integrity and indirectly LAP1B activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Influences glycogen synthase kinase-3 beta (GSK-3β) activity, which is involved in multiple cellular processes, including those potentially linked to LAP1B. | ||||||