KRTAP21-2 Inhibitors
KRTAP21-2 inhibitors represent a class of chemical compounds designed to target and regulate the activity of the keratin-associated protein 21-2 (KRTAP21-2). KRTAP proteins, including KRTAP21-2, are essential components of the structural framework within hair and wool fibers, playing a critical role in cross-linking with keratins to stabilize the hair's mechanical properties. Inhibitors of KRTAP21-2 typically interact with this protein's structure or its functional pathways, modulating its ability to associate with other keratin-associated proteins or keratins themselves. The development of KRTAP21-2 inhibitors often involves an understanding of the molecular interactions within the intermediate filaments where keratin and associated proteins form highly cross-linked networks, providing strength and elasticity to hair.
These inhibitors may be tailored to bind to specific sites on the KRTAP21-2 protein, interfering with its folding, association, or function within the keratin matrix. Modulation of these interactions can lead to changes in the assembly and organization of keratin fibers, potentially affecting their properties at a molecular level. KRTAP21-2 inhibitors are of interest for studying the fundamental biological processes governing keratin structure, as well as for the exploration of the biophysical characteristics of hair fiber formation and degradation. Understanding the structural biology of KRTAP21-2 and the effects of its inhibition can provide insights into the broader regulatory mechanisms of protein-protein interactions within keratin-based systems.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog could incorporate into the KRTAP21-2 gene's promoter region during DNA replication, causing DNA demethylation and consequent transcriptional silencing. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, this compound may lead to the accumulation of acetylated histones, potentially resulting in the repression of KRTAP21-2 due to altered chromatin structure. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
As a non-nucleoside DNA methyltransferase inhibitor, RG 108 could prevent the methylation of the KRTAP21-2 promoter, leading to a decrease in gene transcription. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This compound could be incorporated into DNA and trap DNA methyltransferases, thus reducing the methylation of the KRTAP21-2 gene and subsequently inhibiting its expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may induce hyperacetylation of histones in the KRTAP21-2 gene promoter, which could repress transcription and lower the protein levels. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
This inhibitor may specifically alter histone acetylation patterns of the KRTAP21-2 gene, resulting in a compact chromatin state that represses transcription. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to GC-rich DNA sequences, Mithramycin A could disrupt transcription factor binding to the KRTAP21-2 promoter, thereby downregulating its expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can intercalate into DNA, which may block the access of transcriptional machinery to the KRTAP21-2 gene, leading to a decrease in its expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide may inhibit RNA polymerase II activity, which could lead to a reduction in the transcription of a broad range of genes, including KRTAP21-2. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR, Rapamycin could decrease the translation of many mRNAs, potentially including those of KRTAP21-2, resulting in reduced protein synthesis. | ||||||