KRTAP20-2 Inhibitors
KRTAP20-2 inhibitors are a specialized class of chemical compounds that function by targeting keratin-associated protein 20-2 (KRTAP20-2), a member of the keratin-associated protein family. These proteins are integral to the structure and function of hair, nails, and other keratinized tissues, as they interact with keratin intermediate filaments to stabilize and maintain the rigidity of these structures. KRTAP20-2 plays a role in the assembly of hair fibers, contributing to their mechanical properties. Inhibitors of KRTAP20-2, therefore, work by disrupting this interaction, leading to modifications in the architecture and behavior of keratinized tissues, specifically within hair fiber formation.
Structurally, KRTAP20-2 inhibitors typically exhibit a high degree of specificity towards their target, often designed to interfere with the protein's conformation or its ability to bind keratin filaments. This specificity arises from interactions with key residues in the KRTAP20-2 protein that are crucial for its function. The chemical frameworks of these inhibitors vary, but they usually contain functional groups capable of forming hydrogen bonds or engaging in hydrophobic interactions with the target protein, enabling strong and selective binding. Research into KRTAP20-2 inhibitors often focuses on understanding the molecular mechanisms underlying these interactions and the effects of inhibition on keratinized tissue properties at a biochemical and structural level.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may downregulate KRTAP20-2 expression by inducing hypomethylation of its gene promoter, thus repressing transcription initiation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could decrease KRTAP20-2 expression by enhancing histone acetylation, leading to tight chromatin conformation that obstructs the transcriptional machinery's access to the gene. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may downregulate KRTAP20-2 by maintaining histones in a hyperacetylated state, interfering with the assembly of transcriptional activators at the gene locus. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A could inhibit KRTAP20-2 transcription by binding to GC-rich sequences in its promoter region, preventing the binding of specific transcription factors required for gene activation. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may reduce KRTAP20-2 expression by activating retinoic acid receptors that repress the transcription of certain hair follicle-related genes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin might suppress KRTAP20-2 expression by inhibiting NF-κB signaling, which is known to play a role in the transcriptional regulation of various genes. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate could decrease KRTAP20-2 expression by inhibiting DNA methyltransferases, leading to the demethylation of gene promoters and subsequent transcriptional repression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may inhibit KRTAP20-2 expression through activation of SIRT1, leading to deacetylation of transcription factors and reduced transcriptional activity at the KRTAP20-2 gene locus. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane could downregulate KRTAP20-2 expression by activating Nrf2 which then binds to antioxidant response elements in the promoters of target genes, potentially including KRTAP20-2, resulting in transcriptional repression. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may reduce KRTAP20-2 expression by activating glucocorticoid receptors which then translocate to the nucleus and interact with glucocorticoid response elements in the KRTAP20-2 promoter, leading to transcriptional repression. | ||||||