KRTAP15-1 Inhibitors
KRTAP15-1 inhibitors refer to a class of chemical compounds that specifically target and inhibit the activity or expression of the KRTAP15-1 gene or its associated proteins. KRTAP15-1 (Keratin-associated protein 15-1) belongs to the broader family of keratin-associated proteins (KRTAPs), which are integral to the structural and functional properties of keratin fibers, particularly in the formation of hair and nails. These proteins interact with keratins to stabilize and cross-link the keratin fibers, contributing to the overall strength and flexibility of these tissues. Inhibitors of KRTAP15-1 act by disrupting the normal function of these proteins, potentially affecting the assembly or structural integrity of keratin filaments and their associated microstructures. The exact mechanisms by which these inhibitors function can involve direct interaction with the protein itself or interference with gene expression, protein folding, or post-translational modifications that are crucial for KRTAP15-1 activity.
Chemically, KRTAP15-1 inhibitors may include small molecules, peptides, or nucleic acid-based compounds designed to bind to the active site or specific motifs within the protein, preventing it from interacting with keratin or other proteins in its pathway. The inhibitors could also affect regulatory elements of KRTAP15-1 expression, such as transcription factors or epigenetic modifications, resulting in decreased synthesis of the protein. These inhibitors are useful in studying the molecular role of KRTAP15-1 in keratin-related processes and provide valuable insights into how keratin-associated proteins contribute to the physical properties of keratin-based structures. Detailed biochemical and structural studies of these inhibitors allow researchers to better understand the nuances of KRTAP15-1 function and the broader interactions within the keratin network.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent may prompt DNA demethylation specifically at the KRTAP15-1 gene promoter, potentially leading to transcriptional silencing of the gene by altering the binding affinity of DNA-binding proteins that control gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylases, Trichostatin A could induce hyperacetylation of histones near the KRTAP15-1 gene. This change may result in a closed chromatin conformation that decreases the accessibility of the gene to transcriptional enzymes. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A could bind to specific DNA sequences in the KRTAP15-1 promoter, obstructing the assembly of transcriptional machinery, thus directly diminishing the transcriptional rate of the KRTAP15-1 gene. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
Hydroxyurea could disrupt the DNA synthesis phase during cell division, thereby potentially hindering the replication of cells expressing KRTAP15-1. This disruption might result in a reduced level of KRTAP15-1 expression in proliferating cell populations. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate, a histone deacetylase inhibitor, could cause chromatin to remain in a hyperacetylated state, leading to transcriptional repression of the KRTAP15-1 gene by preventing transcription factors from accessing the gene's promoter region. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
By inhibiting histone deacetylase activity, Suberoylanilide Hydroxamic Acid may lead to an increase in acetylated histones, thereby condensing the chromatin at the KRTAP15-1 locus and reducing the gene's transcriptional activity through decreased promoter accessibility. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram could interfere with acetaldehyde metabolism, which may secondarily decrease the cellular concentrations of cofactors required for transcription factor activity at the KRTAP15-1 promoter, leading to reduced expression of the gene. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid could downregulate the expression of KRTAP15-1 by hindering specific cell signaling pathways crucial for the transcriptional initiation at the KRTAP15-1 gene promoter, resulting in decreased synthesis of the mRNA transcript. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate may have a direct effect on the transcription factors binding to the KRTAP15-1 promoter, reducing their activity and consequently leading to a diminished transcription of the KRTAP15-1 gene. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D could intercalate into DNA, specifically at transcription initiation complexes, hindering RNA polymerase progression along the KRTAP15-1 gene. This binding could result in a blockade of KRTAP15-1 mRNA transcription. | ||||||