Date published: 2025-10-10

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KRTAP10-8 Inhibitors

Keratin Associated Protein 10-8 (KRTAP10-8) belongs to a vast family of keratin-associated proteins (KRTAPs). These proteins are integral constituents of the hair shaft, and they play a pivotal role in defining the mechanical properties and resilience of hair. The intricacy of hair fiber is attributed to the complex interplay between keratins and KRTAPs. Within this symphony of interactions, KRTAP10-8 is believed to contribute specifically to the structure and possibly the texture of hair by interacting with other proteins and forming cross-links. Its precise pathway and interactions, however, are still subjects of ongoing research, as scientists strive to elucidate the exact mechanisms that govern hair formation and strength at the molecular level.

KRTAP10-8 inhibitors represent a class of molecules specifically designed to target and inhibit the function or expression of KRTAP10-8. By curbing its activity, researchers can derive crucial information regarding its role in hair physiology. Chemical inhibition of KRTAP10-8 could lead to observable changes in hair properties, which can be analyzed to infer the protein's precise role. Such inhibitors work by interfering with the protein's ability to bind with its partners, by preventing its proper folding or by blocking its synthesis altogether. By delving into the realm of KRTAP10-8 inhibition, researchers could open doors to a deeper comprehension of hair biology at its most fundamental level.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Actinomycin D could bind specifically to regions of the KRTAP10-8 gene, preventing its transcription into RNA.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

This compound might selectively block the translation of KRTAP10-8 mRNA, halting its protein production.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

If KRTAP10-8 synthesis is mTOR-dependent, rapamycin could inhibit its production by impeding the mTOR pathway.

Mycophenolic acid

24280-93-1sc-200110
sc-200110A
100 mg
500 mg
$68.00
$261.00
8
(1)

By inhibiting IMP dehydrogenase, this compound might reduce precursors necessary for KRTAP10-8 gene transcription.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

This compound might modify the methylation patterns of the KRTAP10-8 gene, repressing its expression.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

This HDAC inhibitor might alter the acetylation state of histones around the KRTAP10-8 gene, possibly repressing its transcription.

α-Amanitin

23109-05-9sc-202440
sc-202440A
1 mg
5 mg
$260.00
$1029.00
26
(2)

By inhibiting RNA polymerase II, this compound could specifically halt the transcription of KRTAP10-8 mRNA.

Camptothecin

7689-03-4sc-200871
sc-200871A
sc-200871B
50 mg
250 mg
100 mg
$57.00
$182.00
$92.00
21
(2)

By impeding DNA topoisomerase I, camptothecin could disrupt the replication and transcription of the KRTAP10-8 gene.

2-Deoxy-D-glucose

154-17-6sc-202010
sc-202010A
1 g
5 g
$65.00
$210.00
26
(2)

Inhibition of glycolysis might reduce the cellular energy, potentially impairing the synthesis of specific proteins like KRTAP10-8.

DRB

53-85-0sc-200581
sc-200581A
sc-200581B
sc-200581C
10 mg
50 mg
100 mg
250 mg
$42.00
$185.00
$310.00
$650.00
6
(1)

DRB's potential inhibition of RNA polymerase II might lead to reduced synthesis of KRTAP10-8 mRNA.