Keratin Associated Protein 10-8 (KRTAP10-8) belongs to a vast family of keratin-associated proteins (KRTAPs). These proteins are integral constituents of the hair shaft, and they play a pivotal role in defining the mechanical properties and resilience of hair. The intricacy of hair fiber is attributed to the complex interplay between keratins and KRTAPs. Within this symphony of interactions, KRTAP10-8 is believed to contribute specifically to the structure and possibly the texture of hair by interacting with other proteins and forming cross-links. Its precise pathway and interactions, however, are still subjects of ongoing research, as scientists strive to elucidate the exact mechanisms that govern hair formation and strength at the molecular level.
KRTAP10-8 inhibitors represent a class of molecules specifically designed to target and inhibit the function or expression of KRTAP10-8. By curbing its activity, researchers can derive crucial information regarding its role in hair physiology. Chemical inhibition of KRTAP10-8 could lead to observable changes in hair properties, which can be analyzed to infer the protein's precise role. Such inhibitors work by interfering with the protein's ability to bind with its partners, by preventing its proper folding or by blocking its synthesis altogether. By delving into the realm of KRTAP10-8 inhibition, researchers could open doors to a deeper comprehension of hair biology at its most fundamental level.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D could bind specifically to regions of the KRTAP10-8 gene, preventing its transcription into RNA. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
This compound might selectively block the translation of KRTAP10-8 mRNA, halting its protein production. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
If KRTAP10-8 synthesis is mTOR-dependent, rapamycin could inhibit its production by impeding the mTOR pathway. | ||||||
Mycophenolic acid | 24280-93-1 | sc-200110 sc-200110A | 100 mg 500 mg | $68.00 $261.00 | 8 | |
By inhibiting IMP dehydrogenase, this compound might reduce precursors necessary for KRTAP10-8 gene transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound might modify the methylation patterns of the KRTAP10-8 gene, repressing its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This HDAC inhibitor might alter the acetylation state of histones around the KRTAP10-8 gene, possibly repressing its transcription. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
By inhibiting RNA polymerase II, this compound could specifically halt the transcription of KRTAP10-8 mRNA. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
By impeding DNA topoisomerase I, camptothecin could disrupt the replication and transcription of the KRTAP10-8 gene. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
Inhibition of glycolysis might reduce the cellular energy, potentially impairing the synthesis of specific proteins like KRTAP10-8. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
DRB's potential inhibition of RNA polymerase II might lead to reduced synthesis of KRTAP10-8 mRNA. |