KLRF2 Activators
KLRF2 Activators are a diverse group of chemical compounds that indirectly enhance the functional activity of KLRF2, a key protein in natural killer (NK) cell-mediated immune responses. These activators work through various signaling pathways and cellular processes to strengthen KLRF2's role in the immune system. For instance, Epigallocatechin gallate and Andrographolide, by inhibiting NF-kB, promote the upregulation of NKG2D ligands, which are crucial for KLRF2-mediated NK cell activation. Similarly, Curcumin, through modulation of the JAK/STAT pathway, and Ursolic acid, by influencing the MAPK pathway, enhance the cytotoxic response of NK cells, indirectly boosting KLRF2 activity. Resveratrol's activation of SIRT1 and Sulforaphane's activation of Nrf2 also contribute to this enhancement by improving NK cell functionality and resilience to oxidative stress, respectively.
The impact of these activators on KLRF2 is further exemplified by compounds like Quercetin, Genistein, and Piperine, which modulate key signaling pathways within NK cells. Quercetin inhibits PI3K, while Genistein, as a tyrosine kinase inhibitor, affects several signaling routes, both leading to an enhanced immune response mediated by KLRF2. Piperine's effect on the NF-kB pathway aligns with this mechanism, further amplifying KLRF2's role in immune surveillance. Additionally, Indole-3-carbinol and Berberine influence immune responses through estrogen metabolism and metabolic pathways, respectively, adding layers of regulatory control that benefit KLRF2's function in NK cells. Capsaicin's unique role in activating TRPV1 channels also supports this enhancement, demonstrating the diverse biochemical pathways through which KLRF2 activators operate to strengthen NK cell-mediated immune surveillance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin gallate inhibits NF-kB, a transcription factor involved in inflammatory responses. Inhibition of NF-kB can lead to the upregulation of NKG2D ligands, including those that interact with KLRF2, thereby enhancing KLRF2-mediated natural killer cell activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates the JAK/STAT pathway, which is crucial for NK cell function. By influencing this pathway, curcumin can enhance the functional activity of KLRF2 in natural killer cells, improving their cytotoxic response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, a protein that modulates immune function. Activation of SIRT1 can enhance NK cell activity, indirectly promoting KLRF2 function in the immune response. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates Nrf2, a key regulator of antioxidant response. This activation can indirectly enhance KLRF2-mediated NK cell activity by improving cellular resilience to oxidative stress. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits PI3K, a pathway involved in NK cell activation. By modulating PI3K, quercetin can indirectly enhance KLRF2 activity in natural killer cells, bolstering their immune response. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol modulates estrogen metabolism, which can influence immune responses. This modulation may indirectly enhance KLRF2 activity in NK cells, augmenting their cytotoxic capability. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide modulates NF-kB activity, influencing immune responses. By affecting this pathway, andrographolide can indirectly enhance KLRF2 activity in NK cells, promoting immune surveillance. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1 channels, which can influence NK cell activity. By modulating these channels, capsaicin may enhance the functional activity of KLRF2 in NK cell-mediated immune responses. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $56.00 $180.00 | 8 | |
Ursolic acid modulates the MAPK pathway, which is involved in NK cell activation. This modulation can lead to enhanced KLRF2 activity in NK cells, augmenting their role in immune surveillance. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, can modulate signaling pathways in NK cells. By influencing these pathways, genistein may enhance KLRF2 activity, strengthening the NK cell-mediated immune response. | ||||||