KIR2.3 Inhibitors

KIR2.3 inhibitors constitutes a diverse array of organic and inorganic compounds that display the distinctive ability to modulate the functional dynamics of KIR2.3 channels, a specific subset of inward rectifying potassium channels pervasive in various physiological systems, including cardiac and neural tissues. The intricate mechanism underlying these inhibitors involves their interaction with discrete structural domains within the KIR2.3 channel protein, notably the pore-forming regions. This engagement elicits a perturbation or adjustment in the conductance of ions, particularly potassium ions, through the central channel pore. The binding event between an inhibitor and the channel protein is an intricate molecular interplay, with distinct inhibitors demonstrating varying affinities and selectivities for KIR2.3 channels. This interaction often triggers a conformational transition within the channel, consequently impeding the natural flow of potassium ions across the cell membrane. It is noteworthy that the inhibitory action exerted by these compounds is a transient and concentration-dependent process, allowing for reversibility of the effect when the inhibitor is no longer present. Within the realm of cellular electrophysiology, the binding of KIR2.3 inhibitors introduces a notable shift in the equilibrium of ion movement, potentially resulting in diverse physiological outcomes.