Kininogen Activators
The chemical class of Kininogen Activators comprises compounds that can indirectly influence the function of Kininogen through modulation of the kallikrein-kinin system, coagulation pathways, and inflammation mechanisms. These compounds, though not directly interacting with Kininogen, play a crucial role in modulating the environment and signaling pathways that can lead to the activation or upregulation of Kininogen's function.
For example, ACE inhibitors such as Captopril and Lisinopril increase the activity of Kininogen by prolonging the action of its cleavage products like bradykinin. Similarly, anticoagulants and thrombin inhibitors like Rivaroxaban and Argatroban can indirectly influence Kininogen's function by modulating coagulation pathways, which are intimately connected with the kallikrein-kinin system. Additionally, compounds like Ecallantide and Berinert, which affect the activity of enzymes like kallikrein and C1 esterase, can alter the dynamics of Kininogen cleavage and function.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $49.00 $91.00 | 21 | |
An ACE inhibitor that prevents bradykinin degradation, indirectly increasing Kininogen activity by prolonging the action of its cleavage products. | ||||||
Heparin | 9005-49-6 | sc-507344 | 25 mg | $119.00 | 1 | |
A low molecular weight heparin that can modulate coagulation and inflammation pathways, potentially influencing Kininogen activity. | ||||||
Fondaparinux | 104993-28-4 | sc-507424 | 10 mg | $297.00 | ||
An anticoagulant that influences blood coagulation pathways, potentially modulating Kininogen's role in these processes. | ||||||
Argatroban | 74863-84-6 | sc-201310 sc-201310A | 10 mg 50 mg | $117.00 $469.00 | 13 | |
A direct thrombin inhibitor that can affect coagulation pathways, indirectly influencing Kininogen activity. | ||||||
Dabigatran | 211914-51-1 | sc-481166 | 5 mg | $205.00 | 1 | |
Another direct thrombin inhibitor, potentially modulating Kininogen's function in coagulation and inflammation. | ||||||
Rivaroxaban | 366789-02-8 | sc-208311 | 2 mg | $158.00 | 18 | |
An inhibitor of Factor Xa in the coagulation cascade, potentially influencing Kininogen's role in blood coagulation. | ||||||
Apixaban | 503612-47-3 | sc-364406 sc-364406A | 10 mg 50 mg | $240.00 $634.00 | 2 | |
Also inhibits Factor Xa, indirectly affecting Kininogen activity within the coagulation and inflammation pathways. | ||||||