KIAA1430_4933411K20Rik Activators
KIAA1430_4933411K20Rik activators encompass a range of chemical compounds that, through various mechanisms, serve to enhance the functional activity of the protein. For example, chemicals such as Forskolin and 8-Bromo-cAMP may increase intracellular cAMP levels, thereby stimulating protein kinase A (PKA) which in turn could phosphorylate and activate KIAA1430_4933411K20Rik if it is a substrate of PKA or is positively regulated by PKA-activated pathways. Similarly, IBMX's role in inhibiting phosphodiesterases prevents the degradation of cAMP and cGMP, leading to sustained activation of PKA or PKG, which could have a downstream effect on the activity of KIAA1430_4933411K20Rik. PMA's activation of protein kinase C (PKC) and Ionomycin's elevation of intracellular calcium could both activate signaling pathways involving calmodulin-dependent kinases (CaMK), which may enhance KIAA1430_4933411K20Rik activity. Epigallocatechin gallate (EGCG) may also shift signaling by inhibiting competing kinases, indirectly favoring activation mechanisms specific to KIAA1430_4933411K20Rik.
Further, SNAP, by releasing nitric oxide and activating guanylate cyclase, can indirectly enhance the functional activity of KIAA1430_4933411K20Rik through cGMP-dependent protein kinase (PKG) pathways. A23187 and Ouabain, through the modulation of intracellular calcium and ion homeostasis, respectively, trigger calcium-dependent signaling pathways, potentially impacting KIAA1430_4933411K20Rik. Inhibitors of protein phosphatases, such as Okadaic Acid and Calyculin A, could lead to a hyperphosphorylated cellular state, potentially enhancing phosphorylation-dependent activation of KIAA1430_4933411K20Rik. Anisomycin, through the activation of stress-activated protein kinases, may also influence the signaling landscape to favor KIAA1430_4933411K20Rik activation. Collectively, these compounds, through their targeted cellular effects, may enhance the activity of KIAA1430_4933411K20Rik without direct binding or influencing its expression levels.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents the breakdown of cAMP and cGMP, leading to their accumulation. This elevation can indirectly enhance KIAA1430_4933411K20Rik activity by sustaining the activation of PKA or PKG pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to a cascade of phosphorylation events that could enhance the activity of KIAA1430_4933411K20Rik by altering its conformation or interaction with other proteins. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations, potentially activating calcium-dependent kinases such as calmodulin-dependent kinase (CaMK). This increase in calcium signaling could indirectly enhance the activity of KIAA1430_4933411K20Rik through phosphorylation events. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase inhibitory activity. By inhibiting certain kinases, EGCG could shift signaling pathways to favor the activation of KIAA1430_4933411K20Rik by reducing competitive phosphorylation events. | ||||||
(±)-S-Nitroso-N-acetylpenicillamine | 79032-48-7 | sc-200319B sc-200319 sc-200319A | 10 mg 20 mg 100 mg | $73.00 $112.00 $367.00 | 18 | |
SNAP releases nitric oxide (NO) which can activate soluble guanylate cyclase and increase cGMP levels, subsequently activating PKG pathways. This activation could enhance the functional activity of KIAA1430_4933411K20Rik through downstream signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that facilitates the influx of calcium ions, similar to Ionomycin, and can thus activate calcium-dependent signaling pathways that may enhance the functional activity of KIAA1430_4933411K20Rik. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
8-Bromo-cAMP is a cell-permeable cAMP analog that activates PKA. Increased PKA activity could lead to the phosphorylation and enhancement of KIAA1430_4933411K20Rik function within its relevant signaling pathways. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases 1 and 2A, leading to increased phosphorylation levels within the cell. This can indirectly enhance the phosphorylation state and activity of KIAA1430_4933411K20Rik. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Calyculin A is also an inhibitor of protein phosphatases, particularly PP1 and PP2A, and can similarly to Okadaic Acid, lead to the enhanced activity of KIAA1430_4933411K20Rik through increased phosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that can activate stress-activated protein kinases (SAPKs) and p38 MAPK. Activation of these kinases can lead to signaling changes that enhance the activity of KIAA1430_4933411K20Rik. | ||||||