KIAA1107 Activators
Chemical activators of KIAA1107 can engage distinct cellular signaling pathways, leading to its activation through various intracellular events. Forskolin, by increasing cyclic AMP (cAMP) levels, activates adenylate cyclase, which in turn stimulates cAMP-dependent pathways. This elevation of cAMP can lead to the activation of protein kinase A (PKA) and subsequent phosphorylation of proteins within the signaling cascade that includes KIAA1107. Similarly, Isoproterenol also raises cAMP levels by activating beta-adrenergic receptors, which indirectly promotes the activation of KIAA1107 through PKA signaling. Dibutyryl-cAMP, a membrane-permeable cAMP analog, mimics this effect by directly increasing intracellular cAMP, thus activating PKA and EPAC pathways that can engage KIAA1107.
Ionomycin, by serving as a calcium ionophore, causes a significant increase in intracellular calcium levels, activating calcium-dependent signaling pathways that KIAA1107 is part of. Thapsigargin also raises intracellular calcium by inhibiting the SERCA pump, indirectly leading to KIAA1107 activation. In parallel, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is known to phosphorylate and activate proteins like KIAA1107. Epidermal Growth Factor (EGF) stimulates its receptor pathway, leading to downstream signaling events through the MAPK/ERK pathway that can culminate in KIAA1107 activation. Insulin works through its receptor to activate the PI3K/AKT pathway, influencing several downstream targets and pathways that include KIAA1107. Anisomycin activates stress-activated protein kinases, such as JNK, which can also lead to the activation of KIAA1107 as part of the cellular response to stress signals. Moreover, Calyculin A and Okadaic Acid increase protein phosphorylation by inhibiting phosphatases, which can result in the activation of pathways involving KIAA1107. Hydrogen Peroxide triggers oxidative stress-related pathways by serving as a signaling molecule, which can lead to the activation of kinases that target KIAA1107, thereby contributing to its activation in response to oxidative signals. These chemicals, through their unique mechanisms, engage and modulate various signaling networks within the cell, ultimately leading to the activation of KIAA1107.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calcium-dependent signaling pathways. Elevated calcium levels can lead to the activation of KIAA1107 through calcium-sensitive signaling networks that KIAA1107 is a part of. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is involved in numerous signaling pathways. PKC activation can lead to the phosphorylation and activation of downstream proteins, including KIAA1107, as part of the PKC-mediated signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that activates adrenergic receptors, leading to the activation of protein kinase A (PKA). PKA can phosphorylate various substrates, including proteins in the signaling pathway in which KIAA1107 operates, resulting in the activation of KIAA1107. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin binds to its receptor and activates the PI3K/AKT signaling pathway. AKT can activate various downstream targets, including those in pathways involving KIAA1107. The activation of these pathways can lead to the functional activation of KIAA1107. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is known to activate stress-activated protein kinases such as JNK. The activation of these kinases can lead to the activation of transcription factors and other proteins that are part of the signaling network that includes KIAA1107, leading to its activation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is a potent inhibitor of certain phosphatases, which leads to an increase in protein phosphorylation. The inhibition of phosphatases can result in the activation of signaling pathways that include KIAA1107, culminating in the protein's activation. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Similar to Calyculin A, Okadaic Acid inhibits protein phosphatases 1 and 2A, causing an increase in phosphorylation within cells. This can activate signaling pathways that involve KIAA1107, indirectly leading to the activation of KIAA1107 as a consequence of altered signaling dynamics. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $31.00 $61.00 $95.00 | 28 | |
Hydrogen Peroxide serves as a signaling molecule that can lead to the activation of various oxidative stress-related pathways. These pathways can include the activation of kinases that phosphorylate KIAA1107, resulting in its activation as a response to changes in the cellular redox state. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor which causes a rise in intracellular calcium levels. This increase in calcium can activate calcium-dependent signaling mechanisms that KIAA1107 is a part of, leading to the activation of KIAA1107 through these pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP is a cAMP analog that can permeate cell membranes and effectively raise the intracellular level of cAMP, which can activate PKA and EPAC signaling pathways. Through these pathways, KIAA1107 can be activated as part of the cell's response to elevated cAMP levels. | ||||||