KIAA0317 Activators
KIAA0317 Activators are a class of chemical compounds that directly or indirectly enhance the functional activity of KIAA0317, a protein directly involved in the PI3K/AKT signaling pathway. Some KIAA0317 activators, such as EGF and Insulin, act as ligands that bind to their respective receptors, triggering the PI3K/AKT pathway. The activation of this pathway leads to the enhanced functional activity of KIAA0317. The action of these ligands exemplifies how receptor-ligand interactions can activate intracellular signaling cascades, leading to the enhanced functional activity of KIAA0317.
Other KIAA0317 activators enhance the functional activity of KIAA0317 by inhibiting the key components of the PI3K/AKT pathway. These include PI3K inhibitors (NVP-BEZ235, BAY 80-6946) and AKT inhibitors (Ipatasertib, Triciribine, Perifosine,Akti-1/2, MK-2206). By inhibiting these key components, which are upstream or at the same level of KIAA0317 in the PI3K/AKT signaling pathway, the functional activity of KIAA0317 can be enhanced. This underlines the essential role of pathway inhibitors in controlling the activation of proteins within the signaling pathway. The inhibitors of PI3K/AKT pathway components display a potent capacity to enhance KIAA0317 activation, demonstrating the relevance of this pathway in regulating KIAA0317 functional activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin is a hormone that activates the PI3K/AKT signaling pathway. As KIAA0317 is involved in this pathway, the activation by insulin leads to the enhanced functional activity of KIAA0317. | ||||||
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone | sc-501166 | 5 mg | $540.00 | |||
Ipatasertib is an AKT inhibitor that enhances the functional activity of KIAA0317 by inhibiting AKT, a kinase involved in the PI3K/AKT pathway, which KIAA0317 is involved in. | ||||||
Triciribine | 35943-35-2 | sc-200661 sc-200661A | 1 mg 5 mg | $102.00 $138.00 | 14 | |
Triciribine is an AKT inhibitor that enhances the functional activity of KIAA0317 by inhibiting AKT, a critical component of the PI3K/AKT pathway, which KIAA0317 is directly involved in. | ||||||
Perifosine | 157716-52-4 | sc-364571 sc-364571A | 5 mg 10 mg | $184.00 $321.00 | 1 | |
Perifosine is an AKT inhibitor that enhances the functional activity of KIAA0317 by inhibiting AKT, a component of the PI3K/AKT signaling pathway, which KIAA0317 is directly involved in. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $207.00 | 8 | |
NVP-BEZ235 is a dual inhibitor of PI3K and mTOR. The inhibition of these key components of the PI3K/AKT pathway enhances the functional activity of KIAA0317, which is directly involved in this pathway. | ||||||
Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 | 612847-09-3 | sc-202048 sc-202048A | 1 mg 5 mg | $204.00 $265.00 | 29 | |
Akti-1/2 is an inhibitor of AKT1 and AKT2. The inhibition of these kinases enhances the functional activity of KIAA0317, given its direct involvement in the PI3K/AKT signaling pathway. | ||||||
MK-2206 dihydrochloride | 1032350-13-2 | sc-364537 sc-364537A | 5 mg 10 mg | $178.00 $325.00 | 67 | |
MK-2206 is an allosteric inhibitor of AKT. By inhibiting AKT, MK-2206 enhances the functional activity of KIAA0317, as KIAA0317 is directly involved in the PI3K/AKT signaling pathway. | ||||||
BAY 80-6946 | 1032568-63-0 | sc-503264 | 5 mg | $551.00 | ||
BAY 80-6946 is a PI3K inhibitor that enhances the functional activity of KIAA0317, as KIAA0317 is directly involved in the PI3K/AKT signaling pathway. | ||||||