Keratin 74 Inhibitors
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, which is required for the synthesis of thymidine, a nucleotide necessary for DNA replication. Keratin 74 is a structural protein that requires cell division for its incorporation into hair follicles. By inhibiting cell proliferation, Methotrexate can reduce the production and incorporation of Keratin 74 into hair structures. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $150.00 $263.00 $518.00 $731.00 $1461.00 | 1 | |
1-β-D-Arabinofuranosylcytosine is incorporated into DNA during the S-phase of the cell cycle, leading to chain termination. It specifically affects rapidly dividing cells, which include those that produce Keratin 74. By inhibiting DNA replication in these cells, 1-β-D-Arabinofuranosylcytosine can decrease Keratin 74 incorporation during hair follicle formation. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, leading to a decrease in deoxyribonucleotide concentrations and subsequent inhibition of DNA synthesis. This inhibition can lead to a decrease in cell division in hair follicle cells, thus reducing the production of Keratin 74. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin is a tetracyclic diterpene that specifically inhibits DNA polymerase alpha and delta, leading to an S-phase arrest in the cell cycle. This can inhibit the proliferation of cells that produce Keratin 74, thereby reducing its synthesis and incorporation into the hair structure. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, preventing DNA replication and transcription. This can lead to a reduction in cell proliferation in hair follicle cells, thereby decreasing the production of Keratin 74. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits DNA topoisomerase II, leading to DNA cleavage and triggering cell cycle arrest at the G2 phase. This inhibition can reduce the proliferation of cells that synthesize Keratin 74, thus inhibiting its production. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin binds to DNA, causing strand breakage and inhibition of replication and transcription. By causing DNA damage in cells producing Keratin 74, Bleomycin can inhibit cell proliferation and thus the production of Keratin 74. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and inhibits their disassembly, leading to cell cycle arrest and inhibition of cell division. This action can inhibit the proliferation of cells involved in the synthesis of Keratin 74, thereby reducing its production. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $102.00 $235.00 $459.00 $1749.00 $2958.00 | 4 | |
Vinblastine binds to tubulin, inhibiting microtubule formation, which is essential for cell division. By preventing cell proliferation, Vinblastine can reduce the production of Keratin 74. | ||||||
Podophyllotoxin | 518-28-5 | sc-204853 | 100 mg | $84.00 | 1 | |
Podophyllotoxin inhibits the polymerization of tubulin, arresting the cell cycle and inhibiting cell division. This can decrease the production of cells synthesizing Keratin 74, therefore inhibiting the production of Keratin 74. | ||||||