KDEL ER Marker Activators
The category of KDEL ER Marker Activators encompasses a diverse array of compounds that, while not directly engaging with or augmenting the KDEL sequence or its associated receptors, play an indirect role in bolstering the efficiency of the KDEL-tagged protein retention and folding system within the endoplasmic reticulum (ER). This class, comprised of chemical chaperones, antioxidants, and stress response modulators, collectively contributes to the modulation of the cellular environment, enhancing the functionality of the KDEL ER marker system. Chemical chaperones like Sodium PBA and TUDCA constitute essential members of this activator class by facilitating the folding of nascent proteins. By doing so, they alleviate the burden on the KDEL retrieval system, indirectly supporting its capacity to maintain proper protein folding within the ER. In a complementary fashion, antioxidants such as Hydroxytyrosol and NAC play a pivotal role in optimizing the redox state of the ER. This optimization creates an environment conducive to efficient protein folding and function, indirectly fostering the effectiveness of the KDEL ER marker system.
Moreover, compounds like Celastrol and GGA, characterized by their ability to induce heat shock responses, contribute to the enhancement of the KDEL ER marker system. By triggering heat shock responses, these compounds elevate the pool of molecular chaperones available within the cellular milieu. This increase in chaperone availability indirectly augments the KDEL ER marker system's capability to handle and retain correctly folded proteins within the ER, thereby playing a crucial role in preserving cellular homeostasis. The intricate interplay between these diverse compounds and the KDEL ER marker system underscores the complex regulatory networks governing protein retention and folding within the ER. Understanding the nuanced ways in which these activators modulate the cellular environment offers valuable insights into strategies for manipulating the efficiency of the KDEL ER marker system in various cellular contexts.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to alleviate ER stress, potentially enhancing the capacity of the KDEL ER marker system by improving the overall protein folding environment within the ER, thus supporting proper protein retention and trafficking. | ||||||
Sodium phenylbutyrate | 1716-12-7 | sc-200652 sc-200652A sc-200652B sc-200652C sc-200652D | 1 g 10 g 100 g 1 kg 10 kg | $77.00 $166.00 $622.00 $5004.00 $32783.00 | 43 | |
As a chemical chaperone, Sodium PBA assists in the correct folding of proteins within the ER, which may indirectly enhance the function of KDEL ER marker system by reducing the burden of misfolded proteins that need to be identified and retrieved. | ||||||
17-DMAG | 467214-20-6 | sc-202005 | 1 mg | $205.00 | 8 | |
An HSP90 inhibitor that, contrary to its role as a stress inducer, at specific concentration levels, can stabilize proteins, potentially enhancing the KDEL ER marker system's ability to retain and manage correctly folded proteins. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
This compound can activate heat shock responses, which in turn can enhance the cellular protein folding capacity and indirectly improve KDEL ER marker function by reducing misfolded protein load. | ||||||
Geranylgeranylacetone | 6809-52-5 | sc-252851 sc-252851A | 10 mg 100 mg | $66.00 $158.00 | 2 | |
GGA induces the expression of heat shock proteins (HSPs), which assist in protein folding within the ER, potentially supporting the KDEL ER marker system by ensuring proper protein structure and reducing the retrieval load. | ||||||
Dimethyl biphenyl-4,4′-dicarboxylate | 792-74-5 | sc-234732 | 25 g | $89.00 | ||
This small molecule has been implicated in the mitigation of ER stress, which might support the proper functioning of KDEL ER marker system by maintaining a balanced protein folding environment. | ||||||
4-Phenylbutyric acid | 1821-12-1 | sc-232961 sc-232961A sc-232961B | 25 g 100 g 500 g | $53.00 $136.00 $418.00 | 10 | |
4-PBA serves as a chemical chaperone, potentially bolstering the KDEL ER marker system's efficiency by aiding in protein folding and reducing the incidence of misfolded proteins within the ER. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin and similar flavonoids have been found to support ER function and reduce ER stress, which may lead to an indirect enhancement of the KDEL ER marker system's capacity for managing ER protein quality control. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Although an HSP90 inhibitor, Geldanamycin at sub-toxic concentrations may trigger protective cellular responses, indirectly supporting the KDEL ER marker system by fortifying the protein folding machinery within the ER. | ||||||
3,4-Dihydroxyphenyl Ethanol | 10597-60-1 | sc-202887 | 10 mg | $112.00 | 6 | |
Known for its antioxidative properties, 3,4-Dihydroxyphenyl Ethanol can potentially enhance the ER environment, indirectly supporting the KDEL ER marker system by mitigating oxidative stress-induced protein misfolding. | ||||||