Kaptin Inhibitors
Kaptin inhibitors are a class of chemical compounds that specifically target the kaptin protein, an actin-binding protein involved in cytoskeletal dynamics and cell motility. Kaptin plays a crucial role in the organization and remodeling of the actin cytoskeleton, which is essential for processes such as cell movement, shape changes, and signal transduction. By interacting with actin filaments, kaptin helps regulate the structural integrity and plasticity of the cytoskeleton, facilitating cellular responses to mechanical stress and environmental signals. Inhibitors of kaptin disrupt these interactions, thereby affecting actin filament assembly and remodeling, which can impair cellular functions that rely on cytoskeletal integrity.
The mechanism of action of kaptin inhibitors typically involves binding to the actin-binding domains of the kaptin protein, preventing it from associating with actin filaments or modulating their organization. By blocking kaptin's ability to regulate the actin cytoskeleton, these inhibitors can alter cell motility, adhesion, and intracellular transport processes, as well as affect the cell's ability to respond to external stimuli. Kaptin inhibitors are valuable tools for studying the molecular mechanisms that govern cytoskeletal dynamics and the role of actin-binding proteins in cellular structure and function. Researchers use these inhibitors to explore how kaptin contributes to cytoskeletal organization and how its disruption impacts processes such as cell migration, division, and mechanical force transduction in a variety of cellular contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By causing DNA hypomethylation, 5-Azacytidine could directly downregulate Kaptin gene expression by promoting a more transcriptionally inactive chromatin state at its promoter region. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This HDAC inhibitor could lead to hyperacetylation of histones near the Kaptin gene, potentially resulting in the repression of its transcription initiation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D may bind specifically to the DNA at the transcription initiation complex site of the Kaptin gene, obstructing RNA polymerase action and reducing Kaptin mRNA synthesis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
By inhibiting mTOR signaling, Rapamycin could decrease the translation of Kaptin mRNA or the stability of the protein, leading to reduced levels of Kaptin in the cell. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin could insert itself between DNA base pairs at the Kaptin gene locus, preventing proper transcriptional machinery assembly and decreasing Kaptin mRNA production. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid's inhibition of HDACs could lead to an open chromatin configuration around the Kaptin gene, paradoxically leading to transcriptional silencing of this gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid might repress the Kaptin gene expression by altering the recruitment of transcriptional repressors to its promoter region, reducing mRNA levels. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
By causing DNA cross-linking, Mitomycin C could hinder RNA polymerase's ability to transcribe the Kaptin gene, leading to a decrease in its expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could lead to the demethylation of the Kaptin gene promoter, which, depending on the cellular context, might repress transcription and thus decrease Kaptin levels. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
Oxaliplatin forms DNA adducts that could obstruct the transcription factors required for Kaptin gene expression, leading to a decrease in its mRNA and protein levels. | ||||||