Junctophilin-3 Activators
Junctophilin-3 Activators are chemical entities that facilitate the enhancement of Junctophilin-3's functional activity by modulating various cellular signaling pathways associated with calcium dynamics and muscle contraction. Ryanodine and 2,5-Di-tert-butylhydroquinone, both interacting with ryanodine receptors, lead to an increase in intracellular calcium by modulating calcium release channel activity, thereby enhancing Junctophilin-3's role in stabilizing excitation-contraction coupling structures. Caffeine, through antagonism of adenosine receptors, and FPL 64176 and Bay K 8644, as L-type calcium channel activators, all contribute to elevated calcium levels, indirectly supporting Junctophilin-3 in reinforcing junctional membrane complexes critical for muscle cell signaling. ML-9, by inhibiting MLCK, reduces muscle contraction, which may in turn necessitate a greater role for Junctophilin-3 in maintaining the structural integrity of muscle cells. Calmidazolium's inhibition of calmodulin-dependent pathways also suggests a similar indirect enhancement of Junctophilin-3's structural support role.
Additionally, compounds like Dantrolene and Tetracaine, which affect calcium release and voltage-gated sodium channels respectively, could indirectly potentiate Junctophilin-3's role in excitation-contraction coupling by stabilizing the junctional membrane complex. Moreover, Thapsigargin and Cyclopiazonic acid, both SERCA pump inhibitors, induce a sustained increase in cytosolic calcium, which can be expected to elevate the demand for Junctophilin-3's functional activity in maintaining the close apposition of the plasma membrane with the endoplasmic/sarcoplasmic reticulum. Collectively, these Junctophilin-3 Activators, through their targeted effects on calcium signaling and muscle cell dynamics, serve to bolster the functional activity of Junctophilin-3, ensuring the maintenance and efficiency of the excitation-contraction coupling process without direct upregulation of the protein or modification of its expression levels.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ryanodine | 15662-33-6 | sc-201523 sc-201523A | 1 mg 5 mg | $223.00 $799.00 | 19 | |
Ryanodine binds to ryanodine receptors which are located on the sarcoplasmic reticulum of muscle cells and are associated with calcium release channels. This binding results in the modulation of calcium ion release, which is crucial for muscle contraction and could thus enhance the functional activity of Junctophilin-3 by stabilizing the junctional membrane complexes and supporting the formation of excitation-contraction coupling structures in muscle cells. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine acts as a stimulant by antagonizing adenosine receptors, which can lead to increased intracellular calcium levels through the phospholipase C pathway. Elevated intracellular calcium can enhance Junctophilin-3's role in the assembly and maintenance of junctional membrane complexes and the regulation of calcium signaling in muscle cells. | ||||||
ML-9 | 105637-50-1 | sc-200519 sc-200519A sc-200519B sc-200519C | 10 mg 50 mg 100 mg 250 mg | $112.00 $449.00 $673.00 $1224.00 | 2 | |
ML-9 is a kinase inhibitor that targets myosin light-chain kinase (MLCK). Inhibition of MLCK can lead to a reduction in muscle contraction and a subsequent need for stabilization of the junctional membrane complexes. This may indirectly enhance the role of Junctophilin-3 by maintaining the structural integrity of the excitation-contraction coupling apparatus in muscle cells. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $156.00 $612.00 | 27 | |
Calmidazolium is a calmodulin inhibitor. By inhibiting calmodulin, it affects calcium signaling pathways, which are critical for muscle contraction. This disruption can potentially increase the importance of Junctophilin-3 in stabilizing the junctional membrane complex and maintaining excitation-contraction coupling efficiency in muscle cells. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene interacts with the ryanodine receptor to inhibit calcium release from the sarcoplasmic reticulum. By modulating the calcium release, it can indirectly enhance the stability of junctophilin-3's role in maintaining the close apposition of the plasma membrane and the endoplasmic/sarcoplasmic reticulum for proper muscle function. | ||||||
Tetracaine | 94-24-6 | sc-255645 sc-255645A sc-255645B sc-255645C sc-255645D sc-255645E | 5 g 25 g 100 g 500 g 1 kg 5 kg | $66.00 $309.00 $500.00 $1000.00 $1503.00 $5000.00 | ||
Tetracaine is a local anesthetic that blocks voltage-gated sodium channels. By inhibiting these channels, it can alter membrane potential and calcium dynamics, potentially enhancing the role of Junctophilin-3 in stabilizing the junctional membrane complexes needed for excitation-contraction coupling in muscle cells. | ||||||
FPL-64176 | 120934-96-5 | sc-201491 | 5 mg | $83.00 | 1 | |
FPL 64176 is a calcium channel activator which increases calcium influx through L-type calcium channels. Enhanced calcium influx can indirectly support Junctophilin-3's function in bridging the sarcoplasmic reticulum to the plasma membrane, which is crucial for muscle contraction and signaling. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $84.00 $196.00 $817.00 | ||
Bay K 8644 is another L-type calcium channel activator. It prolongs the opening of these channels, leading to increased calcium entry into muscle cells. This elevation in intracellular calcium may enhance Junctophilin-3's role in the formation and maintenance of junctional membrane complexes that are essential for excitation-contraction coupling. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that causes a sustained increase in cytosolic calcium by preventing its reuptake into the sarcoplasmic reticulum. Elevated cytosolic calcium could indirectly enhance the role of Junctophilin-3 in the structural organization of the excitation-contraction coupling machinery by stabilizing the junctional complexes between the plasma membrane and sarcoplasmic reticulum. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic acid is another inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps, similar to Thapsigargin, it leads to increased cytosolic calcium | ||||||