JDP2 Inhibitors
JDP2 inhibitors belong to a distinctive chemical class designed to modulate the activity of the c-Jun dimerization protein 2 (JDP2), a transcription factor that plays a crucial role in various cellular processes. The primary function of JDP2 is to regulate gene expression by forming complexes with other transcription factors, notably c-Jun and ATF2, to modulate their activity. These interactions are pivotal in orchestrating cellular responses to stress, proliferation, and differentiation. JDP2 inhibitors act by selectively binding to the active site of JDP2, disrupting its ability to interact with partner proteins and consequently altering the transcriptional landscape within the cell.
JDP2 inhibitors typically comprise specific chemical moieties that enable them to interact with key amino acid residues in the active site of JDP2. This binding affinity allows for the precise modulation of JDP2 activity, making these inhibitors promising tools for elucidating the biological functions governed by this transcription factor. By interfering with JDP2-mediated transcriptional regulation, these inhibitors hold potential applications in basic research, contributing to a deeper understanding of the intricate molecular mechanisms underlying cellular processes.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor that can reduce JDP2 activity by preventing its phosphorylation and activation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
An MEK inhibitor that can indirectly reduce JDP2 transcriptional activity by affecting ERK signaling. | ||||||
Kenpaullone | 142273-20-9 | sc-200643 sc-200643A sc-200643B sc-200643C | 1 mg 5 mg 10 mg 25 mg | $61.00 $153.00 $231.00 $505.00 | 1 | |
A cyclin-dependent kinase inhibitor that might indirectly affect JDP2 by altering cell cycle-related signaling pathways. | ||||||
Chelerythrine | 34316-15-9 | sc-507380 | 100 mg | $540.00 | ||
A PKC inhibitor that could alter AP-1 activity and thereby affect JDP2's role in gene transcription. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
A p38 MAP kinase inhibitor which might reduce JDP2 activity by impacting its phosphorylation state. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can indirectly affect JDP2 activity through AKT signaling pathways. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Another PI3K inhibitor that could alter JDP2 activity by modulating downstream signaling pathways. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A compound known to inhibit the activity of various transcription factors, possibly affecting JDP2. | ||||||