JAKMIP3 Activators
Chemical activators of JAKMIP3 employ diverse cellular mechanisms to initiate its activation. Staurosporine, a broad-spectrum protein kinase inhibitor, indirectly activates JAKMIP3 by inhibiting a kinase responsible for JAKMIP3's inactivity, thus resulting in an increase in JAKMIP3 activity. Prostaglandin E2 operates through its receptor to raise intracellular cAMP levels, activating protein kinase A (PKA), which can subsequently phosphorylate and activate JAKMIP3. Similarly, Forskolin, by elevating cAMP, indirectly activates PKA, leading to the activation of JAKMIP3. Epidermal Growth Factor (EGF) binds to its specific receptor, triggering the PI3K/AKT pathway, which can lead to JAKMIP3 activation through subsequent phosphorylation events. Phorbol 12-myristate 13-acetate (PMA) engages protein kinase C (PKC), which is known to phosphorylate and activate JAKMIP3 as part of its signaling cascade.
Ionomycin increases intracellular calcium, activating calmodulin-dependent kinases that can phosphorylate JAKMIP3. Thapsigargin raises cytosolic calcium levels by inhibiting SERCA, which leads to the activation of calcium-dependent kinases capable of activating JAKMIP3. Okadaic Acid and Calyculin A inhibit protein phosphatase 2A, resulting in increased phosphorylation levels of proteins, including JAKMIP3. Anisomycin activates the JNK and p38 MAP kinase pathways, leading to JAKMIP3 activation. Phosphatidic Acid acts as a second messenger to activate mTOR and PKC pathways, which can result in JAKMIP3 activation. Lastly, PF-4708671 selectively inhibits p70 S6 kinase, which can lead to the compensatory activation of other kinases or pathways that activate JAKMIP3, showcasing the intricate network of cellular signaling that converges on the regulation of this particular protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases, but interestingly, it can non-specifically activate Janus kinase and microtubule interacting protein 3 (JAKMIP3) through the inhibition of a kinase that normally maintains JAKMIP3 in an inactive state. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 binds to its G-protein-coupled receptor, leading to an increase in cAMP levels, which can activate PKA. PKA then phosphorylates target proteins, which could include the activation of JAKMIP3 as part of downstream signaling. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and activate JAKMIP3 as part of downstream signaling events. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin increases intracellular cAMP by activating adenylate cyclase, which activates PKA, and PKA can then phosphorylate and activate JAKMIP3. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin increases intracellular calcium levels, which can activate calmodulin-dependent kinases, and these kinases can phosphorylate and activate JAKMIP3. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), raising cytosolic calcium levels, which activates calcium-dependent kinases that could phosphorylate and activate JAKMIP3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatase 2A, leading to increased phosphorylation levels of cellular proteins, which could result in the activation of JAKMIP3. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Similar to Okadaic Acid, Calyculin A inhibits protein phosphatases, including PP1 and PP2A, which prevents dephosphorylation of proteins, potentially resulting in the activation of JAKMIP3. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates the JNK and p38 MAP kinase pathways, which can lead to the activation of JAKMIP3 through phosphorylation of target proteins within these pathways. | ||||||
Phosphatidic Acid, Dipalmitoyl | 169051-60-9 | sc-201057 sc-201057B sc-201057A | 100 mg 250 mg 500 mg | $104.00 $239.00 $409.00 | ||
Phosphatidic Acid can act as a second messenger within cellular membranes, activating mTOR and PKC pathways, which could lead to the activation of JAKMIP3. | ||||||