ITFG2 Inhibitors
In the context of integrin-associated signaling, the term ITFG2 inhibitors generally refers to compounds that, while not directly targeting ITFG2, can modulate the broader pathways, particularly those associated with integrin function and signaling. These compounds predominantly function by inhibiting key components of the integrin signaling network, leading to downstream effects on proteins associated with these pathways, including ITFG2.
Chemicals like Wortmannin, PP2, and Dasatinib directly inhibit critical kinases and components of the integrin signaling pathway. For instance, PI3K, targeted by Wortmannin, plays an essential role in many cellular processes, including those related to integrin function. Similarly, Src kinases, targeted by PP2 and Dasatinib, are central players in integrin-mediated cellular adhesion and migration. The inhibition of these key components disrupts the integrin signaling cascade, leading to altered activity or interactions of proteins like ITFG2 associated with this pathway. Furthermore, small GTPases such as Rac1 and Cdc42 play crucial roles in integrin-mediated cell migration and cytoskeleton reorganization. Compounds like NSC23766 and ML141, which target these GTPases, can thereby influence the functional dynamics of proteins involved in the integrin signaling network. Similarly, inhibitors like Y15, which targets FAK, a central component of integrin signaling involved in cell adhesion, migration, and survival, can have profound effects on the overall integrin signaling pathway and its associated proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor. As PI3K signaling can be central to integrin-mediated signaling, inhibiting PI3K might modify the cellular environment where ITFG2 operates, possibly impeding its function or interactions within integrin-associated pathways. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family kinases. Integrin signaling often involves Src kinases, so by inhibiting Src, PP2 can potentially disrupt the signaling processes where ITFG2 may play a role, influencing its functionality within the integrin signaling framework. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
Dasatinib is a broad-spectrum kinase inhibitor with activity against Src family kinases. Given the role of Src in integrin-mediated signaling, its inhibition could influence the functional dynamics of associated proteins, including ITFG2. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a cell-permeable calcium chelator. By modulating intracellular calcium levels, BAPTA-AM can affect calcium-dependent integrin signaling processes, which might indirectly impede the function of proteins like ITFG2 involved in these pathways. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a Cdc42 inhibitor. Given that Cdc42 is another small GTPase involved in integrin signaling, its inhibition might indirectly affect the functional dynamics of ITFG2 if it plays a role in this signaling cascade. | ||||||
ARP 100 | 704888-90-4 | sc-203522 | 5 mg | $208.00 | 26 | |
ARP 100 is a matrix metalloproteinase-2 (MMP-2) inhibitor. As MMPs can be associated with integrin signaling, the inhibition of MMP-2 could potentially modify the signaling landscape where ITFG2 operates. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
An FGFR1 inhibitor. The fibroblast growth factor receptor (FGFR) pathway can be linked to integrin signaling. By inhibiting FGFR1, PD173074 may alter the signaling environment, potentially impacting proteins like ITFG2 associated with this pathway. | ||||||
EHop-016 | 1380432-32-5 | sc-497382 | 5 mg | $80.00 | ||
An inhibitor of Rac1 and Rac3 GTPase activity. By targeting Rac1/3, EHop-016 could disrupt integrin-associated signaling pathways where ITFG2 might operate, thereby influencing its functional role. | ||||||
FAK Inhibitor 14 | 4506-66-5 | sc-203950 sc-203950A | 10 mg 50 mg | $109.00 $238.00 | 86 | |
Y15 is an inhibitor of focal adhesion kinase (FAK). Given the central role of FAK in integrin signaling, its inhibition can have significant implications on the functional dynamics of proteins involved in this pathway, including potentially ITFG2. | ||||||
PF-562271 | 717907-75-0 | sc-478488 sc-478488A sc-478488B | 5 mg 10 mg 50 mg | $312.00 $474.00 $1124.00 | 3 | |
PF-562,271 is a potent inhibitor of FAK and Pyk2. By targeting these central kinases in integrin-mediated signaling, the compound can significantly disrupt the signaling landscape, which might have implications for proteins like ITFG2. | ||||||