IRX4 Inhibitors
IRX4 Inhibitors are a class of chemical compounds designed to target and inhibit the activity of the Iroquois-class homeodomain protein 4 (IRX4). IRX4 is a transcription factor that plays a critical role in the regulation of gene expression during embryonic development, particularly in the formation and patterning of various tissues and organs. It is a member of the Iroquois gene family, which is conserved across various species and is essential for proper embryogenesis. Inhibition of IRX4 is typically achieved using small molecules or compounds that interfere with its binding to DNA or its interactions with other regulatory proteins.
The study of IRX4 Inhibitors is instrumental in understanding the molecular mechanisms underlying embryonic development and tissue differentiation. By disrupting the function of IRX4, researchers can investigate the consequences on gene expression patterns and developmental processes. This research is valuable in elucidating the genetic and epigenetic factors that drive the formation of various tissues, including the heart, nervous system, and limbs. These inhibitors serve as valuable tools in deciphering the intricacies of gene regulation during embryonic development and contribute to advancing our knowledge of developmental biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can inhibit DNA methyltransferase, potentially demethylating the IRX4 gene promoter and reducing its expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
It is a histone deacetylase inhibitor which may change the chromatin structure around the IRX4 gene, leading to decreased expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor that could lead to epigenetic modulation and consequently lower IRX4 expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
By inhibiting DNA methyltransferase, it may cause hypomethylation and reduce IRX4 mRNA levels indirectly. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
It binds to GC-rich DNA sequences, which could interfere with transcription factors and decrease IRX4 levels. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This intercalating agent inhibits RNA polymerase, potentially reducing IRX4 transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that may lead to a general downregulation of protein synthesis, including IRX4. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
May modulate gene expression and could potentially affect IRX4 transcription. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Affects DNA and RNA synthesis and might non-specifically influence IRX4 gene expression. | ||||||
Ribavirin | 36791-04-5 | sc-203238 sc-203238A sc-203238B | 10 mg 100 mg 5 g | $62.00 $108.00 $210.00 | 1 | |
It may inhibit inosine monophosphate dehydrogenase, potentially affecting RNA metabolism and IRX4 expression. | ||||||