IRGM Activators

IRGM, short for Immunity-Related GTPase M, is a protein that in humans is encoded by the IRGM gene. It is part of the immunity-related GTPases (IRGs), a family of proteins that have critical roles in innate immunity, particularly in the defense against intracellular pathogens.The IRGM protein is an autophagy-inducing factor, meaning it stimulates the process of autophagy within cells. Autophagy is a crucial cellular mechanism responsible for the degradation and recycling of cytoplasmic components, including damaged organelles and proteins. This process is especially important in maintaining cellular homeostasis and in response to stress.

Moreover, IRGM plays a key role in host defense against intracellular bacteria and parasites. Upon infection, IRGM can promote the formation of autophagosomes around the invading pathogen, leading to its eventual destruction and removal from the cell. This mechanism is vital for blocking the spread of infections within the body.Interestingly, genetic variations in the IRGM gene have been associated with an increased risk of certain diseases, notably Crohn's disease, an inflammatory bowel disease. This association suggests that IRGM may have a role in controlling inflammation and immune responses in the gut.