IQCD Inhibitors
Chemical inhibitors of IQCD can function by disrupting the phosphorylation process that is essential for its activity. This phosphorylation is often mediated by protein kinase C (PKC), a family of enzymes that play a vital role in a wide array of cellular processes. Compounds like Bisindolylmaleimide I, Go 6983, Ro-31-8220, Staurosporine, Chelerythrine Chloride, Ruboxistaurin, GF 109203X, Hispidin, Sotrastaurin, Enzastaurin, Balanol, and C1-2 are known to inhibit PKC. By doing so, these inhibitors can interrupt the signaling pathways that rely on PKC activity, which in turn can lead to the inhibition of the functional activity of proteins regulated by PKC, such as IQCD.
The inhibition of PKC by these chemicals can reduce the phosphorylation of IQCD, which is essential for its function. For instance, Bisindolylmaleimide I and GF 109203X share a CAS number, indicating they may be structurally related and could exhibit similar inhibitory effects on PKC, thereby affecting IQCD function. Similarly, Go 6983, a selective PKC inhibitor, can attenuate the kinase's activity, potentially leading to a decrease in IQCD activity. Ro-31-8220 and Staurosporine, although differing in selectivity, can both inhibit PKC, resulting in reduced phosphorylation and subsequent inhibition of IQCD. Chelerythrine Chloride's selective inhibition of PKC could specifically target the phosphorylation events that regulate IQCD. Ruboxistaurin, which specifically targets PKCβ, can inhibit the phosphorylation of IQCD if it is regulated by this particular isoform. Compounds like Hispidin, Sotrastaurin, and C1-2, which are selective towards various PKC isoforms, can also decrease IQCD activity by inhibiting the relevant PKC isoforms that modulate IQCD. Enzastaurin's inhibition of PKCβ and Balanol's broad-spectrum kinase inhibition can both disrupt the phosphorylation signals that modulate IQCD, leading to a decrease in its activity. Thus, these chemical inhibitors can effectively reduce the functional activity of IQCD by targeting the PKC-dependent signaling pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
This compound is a potent and selective inhibitor of protein kinase C (PKC), which is involved in numerous signaling pathways. By inhibiting PKC, Bisindolylmaleimide I could reduce the phosphorylation events that regulate the activity and function of IQCD, resulting in functional inhibition. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $103.00 $293.00 $465.00 | 15 | |
Go 6983 is another selective PKC inhibitor. Given PKC's role in modulating various proteins' functions through phosphorylation, Go 6983's inhibition of PKC may lead to decreased regulation and subsequent inhibition of IQCD's functional activity. | ||||||
Ro 31-8220 | 138489-18-6 | sc-200619 sc-200619A | 1 mg 5 mg | $90.00 $240.00 | 17 | |
As a PKC inhibitor, Ro-31-8220 can prevent PKC from phosphorylating target proteins. If IQCD function is dependent on PKC-mediated signaling, Ro-31-8220 can result in the functional inhibition of IQCD. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Although a broad-spectrum kinase inhibitor, Staurosporine can inhibit PKC with high potency. If IQCD is functionally regulated by PKC, then Staurosporine can indirectly lead to the inhibition of IQCD. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $88.00 $311.00 | 17 | |
This is a selective inhibitor of PKC. By inhibiting PKC, Chelerythrine Chloride can downregulate the phosphorylation and activation of downstream proteins, potentially including IQCD, leading to its inhibition. | ||||||
Ruboxistaurin | 169939-94-0 | sc-507364 | 25 mg | $1080.00 | ||
Ruboxistaurin, also known as LY333531, is a specific inhibitor of PKCβ. If IQCD activity requires PKCβ-mediated phosphorylation, then Ruboxistaurin can inhibit this pathway, leading to the inhibition of IQCD. | ||||||
Hispidin | 555-55-5 | sc-203998 | 5 mg | $408.00 | ||
Hispidin is a PKC inhibitor. By inhibiting PKC, it might reduce the phosphorylation levels of proteins in the PKC-regulated signaling pathways, which can include IQCD, leading to its inhibition. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin is a selective PKC inhibitor, particularly affecting the PKCθ isoform. If IQCD is regulated by PKCθ or another PKC isoform inhibited by Sotrastaurin, this could result in functional inhibition of IQCD. | ||||||
Enzastaurin | 170364-57-5 | sc-364488 sc-364488A sc-364488B | 10 mg 50 mg 200 mg | $254.00 $600.00 $1687.00 | 3 | |
Enzastaurin inhibits PKCβ and has been shown to affect signaling pathways regulated by this enzyme. If IQCD is part of the PKCβ signaling pathway, Enzastaurin could inhibit the functional activity of IQCD. | ||||||
Balanol | 63590-19-2 | sc-503251 | 10 mg | $13500.00 | ||
Balanol is a potent inhibitor of PKC, as well as other kinases. Its inhibition of PKC may lead to a decrease in phosphorylation and activation of proteins that are in the PKC signaling pathway, potentially including IQCD. | ||||||