INO80B Inhibitors
Chemical inhibitors of INO80B encompass a variety of compounds that interfere with its role in chromatin remodeling. Trichostatin A, for instance, works by inhibiting histone deacetylases, which results in the maintenance of acetylated histones. This alteration in histone acetylation status can prevent INO80B from effectively modifying the chromatin structure. Similarly, chloroquine's ability to intercalate into DNA and RNA poses a structural hindrance for DNA-dependent enzymes like INO80B, limiting its interaction with the chromatin substrate. Compounds such as Nocodazole, which impedes microtubule polymerization, affect INO80B indirectly due to the protein's involvement in chromosomal segregation during mitosis-a process that is microtubule-dependent.
Further, the inhibition of cyclin-dependent kinases by DRB, which is crucial for cell cycle progression, may indirectly restrict INO80B's chromatin remodeling activity that is tied to the cell cycle. Etoposide and Camptothecin, which stabilize DNA-topoisomerase complexes, result in DNA breaks and, consequently, an engagement of the cellular repair machinery. This engagement can lead to an indirect inhibition of INO80B's chromatin remodeling functions. Meanwhile, Mimosine and Aphidicolin can bring about a cessation of DNA replication, a phase where INO80B is actively involved, thereby indirectly limiting its activity. Caffeine inhibits DNA repair enzymes, potentially restricting the DNA repair pathways where INO80B operates. Rocaglamide's inhibition of translation initiation can also limit the availability of essential proteins required for INO80B's function. Lastly, MG132, by inhibiting the proteasome, can disrupt the cycling and supply of histones critical for INO80B-mediated chromatin remodeling, implying another indirect method of inhibition. Each of these compounds, through their distinct mechanisms, can influence the ability of INO80B to carry out its role in modifying chromatin structure and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. INO80B, being part of the chromatin remodeling complex, relies on the acetylation status of histones for proper function. Inhibition of deacetylation maintains histones in an acetylated state, thereby inhibiting INO80B's ability to alter chromatin structure. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. As INO80B is involved in chromosomal segregation during mitosis, which is dependent on microtubule formation, nocodazole can indirectly inhibit INO80B by preventing proper chromosome alignment and segregation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine is known to intercalate into DNA and RNA, which can disrupt the function of DNA-dependent enzymes like INO80B by altering the structure of DNA and hampering the access of INO80B to its chromatin substrates. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $42.00 $185.00 $310.00 $650.00 | 6 | |
5,6-Dichlorobenzimidazole riboside (DRB) inhibits cyclin-dependent kinases, which are essential for cell cycle progression. By inhibiting these kinases, DRB can indirectly inhibit INO80B activity, which is involved in cell cycle-related chromatin remodeling. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide stabilizes the DNA-topoisomerase II complex, preventing the ligation step of the DNA breakage-rejoining reaction, leading to DNA breaks. With increased DNA damage, the cellular machinery, including INO80B, focused on repair is engaged, indirectly inhibiting its chromatin remodeling role. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Mimosine is a plant amino acid that inhibits DNA replication. As INO80B plays a role in DNA repair and replication, mimosine can indirectly inhibit INO80B by causing a halt in the DNA replication process where INO80B is normally active. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor, leading to DNA damage by stabilization of the topoisomerase I-DNA cleavable complex. This can indirectly inhibit INO80B by trapping it in a complex with damaged DNA, thus preventing its chromatin remodeling activities. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is an inhibitor of phosphoinositide 3-kinases and can also inhibit DNA repair enzymes at high concentrations. By inhibiting DNA repair pathways, caffeine can indirectly inhibit the function of INO80B, which is involved in DNA damage repair. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $82.00 $300.00 $1082.00 | 30 | |
Aphidicolin is a specific inhibitor of DNA polymerases alpha, delta, and epsilon. Since INO80B has a role in DNA replication, its function can be indirectly inhibited by aphidicolin, which would prevent the progression of replication where INO80B functions. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Bisphenol A has been shown to disrupt various cellular processes including DNA methylation. By altering the methylation status of DNA, Bisphenol A can indirectly inhibit INO80B's ability to interact with chromatin, as this process often depends on DNA's methylation state. | ||||||