IL-3Rα Activators
The chemical class known as IL-3Rα Activators encompasses a group of diverse compounds that can either directly or indirectly stimulate the activity of the Interleukin-3 Receptor Alpha (IL-3Rα). IL-3Rα is a cell surface receptor that plays a crucial role in mediating cellular responses to the cytokine Interleukin-3 (IL-3), a key regulator of hematopoiesis and immune cell function. These activators exert their effects through various mechanisms, primarily by influencing intracellular signaling pathways, cellular processes, or receptor interactions. One group of IL-3Rα activators includes compounds such as SB-431542, Calyculin A, and Forskolin, which indirectly activate IL-3Rα by modulating cellular pathways. SB-431542 inhibits the TGF-β receptor, leading to enhanced IL-3Rα signaling through cross-talk with the TGF-β pathway. Calyculin A, on the other hand, indirectly activates IL-3Rα by inhibiting protein phosphatases (PP1 and PP2A), resulting in increased IL-3Rα phosphorylation and signaling. Forskolin, a potent adenylate cyclase activator, elevates intracellular cAMP levels, subsequently promoting downstream IL-3Rα signaling through the cAMP pathway. These compounds provide insights into how IL-3Rα can be modulated indirectly by targeting cellular signaling cascades.
Another group of activators includes compounds like Compound 48/80 and Thapsigargin, which indirectly activate IL-3Rα through distinct mechanisms. Compound 48/80 stimulates mast cell degranulation, leading to IL-3 release and subsequent IL-3Rα activation. Thapsigargin, on the other hand, indirectly activates IL-3Rα by inhibiting the SERCA pump, resulting in intracellular calcium influx and subsequent modulation of IL-3Rα signaling. These activators exemplify how IL-3Rα can be influenced by extracellular stimuli and calcium signaling events, highlighting the complexity of its regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB-431542 is a chemical compound that activates IL-3Rα by inhibiting the TGF-β receptor, which leads to enhanced IL-3Rα signaling. It indirectly influences IL-3Rα activity through cross-talk with the TGF-β pathway. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A indirectly activates IL-3Rα by inhibiting protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A), leading to increased IL-3Rα phosphorylation and signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates IL-3Rα by stimulating adenylate cyclase, increasing intracellular cAMP levels, and promoting downstream IL-3Rα signaling. It indirectly modulates IL-3Rα through the cAMP pathway. | ||||||
Compound 48/80 trihydrochloride | 94724-12-6 | sc-200736 sc-200736A sc-200736B sc-200736C | 100 mg 250 mg 1 g 5 g | $104.00 $218.00 $843.00 $3756.00 | ||
Compound 48/80 activates IL-3Rα by stimulating mast cell degranulation, leading to the release of IL-3, which binds to IL-3Rα. This indirect activation is mediated by mast cell activation and IL-3 secretion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin indirectly activates IL-3Rα by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, leading to calcium influx, which modulates IL-3Rα signaling. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 activates IL-3Rα by acting as a calcium ionophore, increasing intracellular calcium levels, which in turn influences IL-3Rα signaling pathways. It indirectly impacts IL-3Rα through calcium modulation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin indirectly activates IL-3Rα by acting as a calcium ionophore, elevating intracellular calcium levels, which subsequently affects IL-3Rα signaling pathways. It indirectly influences IL-3Rα via calcium modulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA indirectly activates IL-3Rα by activating protein kinase C (PKC), which can lead to downstream signaling cascades that modulate IL-3Rα activity. It influences IL-3Rα through PKC-mediated pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic Acid (RA) indirectly activates IL-3Rα by influencing retinoic acid receptors (RARs), which can interact with IL-3Rα signaling pathways. It indirectly impacts IL-3Rα through RAR-mediated effects. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $126.00 $328.00 | 30 | |
8-Br-cAMP activates IL-3Rα by serving as a cell-permeable analog of cyclic AMP (cAMP), which stimulates downstream cAMP-dependent pathways that influence IL-3Rα signaling. It indirectly modulates IL-3Rα through cAMP modulation. | ||||||