IFN-α4 inhibitors constitute a distinct class of chemical compounds designed to selectively target and modulate the function of Interferon-alpha 4 (IFN-α4). Interferons are signaling proteins crucial for coordinating immune responses, particularly in defense against viral infections. IFN-α4, as a specific subtype within the interferon-alpha family, exhibits unique structural and functional characteristics. The inhibitors developed for IFN-α4 are intricately designed to interact with specific binding sites on the protein, aiming to disrupt its normal interactions within the cellular environment and potentially influence immune signaling pathways. This selective targeting of IFN-α4 allows researchers to investigate its role in the complex cascade of immune responses, unraveling the intricate mechanisms that govern the communication between cells during an immune challenge.
The molecular architecture of IFN-α4 inhibitors is meticulously crafted to engage with precise regions of the protein, inducing changes in its conformation and dynamics. This interaction holds the potential to impact the protein's ability to transmit signals associated with antiviral defenses. In laboratory research, these inhibitors serve as invaluable tools, enabling scientists to explore the nuanced functions of IFN-α4 in various immune processes and contributing to a deeper understanding of the intricate interplay within the immune system. By manipulating the function of IFN-α4, researchers aim to unravel the complex mechanisms of immune signaling, shedding light on the broader implications for cellular function and the orchestration of immune defenses against viral pathogens. The study of IFN-α4 inhibitors stands at the forefront of advancing our comprehension of immune system dynamics and the finely tuned regulation of antiviral responses within the complex network of the immune system.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to interfere with endosomal acidification which may reduce viral RNA detection, subsequently decreasing IFN-α4 expression. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $103.00 $210.00 $6132.00 | 2 | |
A compound that can inhibit various kinases and may modulate the immune response and interfere with IFN-α4 production. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
A broad kinase inhibitor, including CDK9, which can suppress transcription and potentially decrease IFN-α4 expression. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
A tyrosine kinase inhibitor that may indirectly affect IFN-α4 expression by modulating immune cell signaling. | ||||||
Leflunomide | 75706-12-6 | sc-202209 sc-202209A | 10 mg 50 mg | $20.00 $81.00 | 5 | |
An immunomodulatory agent that inhibits dihydroorotate dehydrogenase and may have a downstream effect on IFN-α4 expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Binds to GC-rich DNA sequences, potentially inhibiting transcription of genes including IFN-α4. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A phosphodiesterase inhibitor which may result in altered cytokine production, potentially affecting IFN-α4 expression. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
A JAK1/2 inhibitor that may reduce the JAK-STAT signaling, subsequently decreasing IFN-α4 production. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
A TGF-β receptor inhibitor that might modulate immune responses and interfere with IFN-α4 expression. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
A bioactive compound in milk thistle that has been shown to have regulatory effects on cellular signaling, potentially affecting IFN-α4. |