Date published: 2025-9-9

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IFN-α4 Inhibitors

IFN-α4 inhibitors constitute a distinct class of chemical compounds designed to selectively target and modulate the function of Interferon-alpha 4 (IFN-α4). Interferons are signaling proteins crucial for coordinating immune responses, particularly in defense against viral infections. IFN-α4, as a specific subtype within the interferon-alpha family, exhibits unique structural and functional characteristics. The inhibitors developed for IFN-α4 are intricately designed to interact with specific binding sites on the protein, aiming to disrupt its normal interactions within the cellular environment and potentially influence immune signaling pathways. This selective targeting of IFN-α4 allows researchers to investigate its role in the complex cascade of immune responses, unraveling the intricate mechanisms that govern the communication between cells during an immune challenge.

The molecular architecture of IFN-α4 inhibitors is meticulously crafted to engage with precise regions of the protein, inducing changes in its conformation and dynamics. This interaction holds the potential to impact the protein's ability to transmit signals associated with antiviral defenses. In laboratory research, these inhibitors serve as invaluable tools, enabling scientists to explore the nuanced functions of IFN-α4 in various immune processes and contributing to a deeper understanding of the intricate interplay within the immune system. By manipulating the function of IFN-α4, researchers aim to unravel the complex mechanisms of immune signaling, shedding light on the broader implications for cellular function and the orchestration of immune defenses against viral pathogens. The study of IFN-α4 inhibitors stands at the forefront of advancing our comprehension of immune system dynamics and the finely tuned regulation of antiviral responses within the complex network of the immune system.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Known to interfere with endosomal acidification which may reduce viral RNA detection, subsequently decreasing IFN-α4 expression.

Emodin

518-82-1sc-202601
sc-202601A
sc-202601B
50 mg
250 mg
15 g
$103.00
$210.00
$6132.00
2
(1)

A compound that can inhibit various kinases and may modulate the immune response and interfere with IFN-α4 production.

Flavopiridol

146426-40-6sc-202157
sc-202157A
5 mg
25 mg
$78.00
$254.00
41
(3)

A broad kinase inhibitor, including CDK9, which can suppress transcription and potentially decrease IFN-α4 expression.

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$25.00
$117.00
$209.00
27
(1)

A tyrosine kinase inhibitor that may indirectly affect IFN-α4 expression by modulating immune cell signaling.

Leflunomide

75706-12-6sc-202209
sc-202209A
10 mg
50 mg
$20.00
$81.00
5
(1)

An immunomodulatory agent that inhibits dihydroorotate dehydrogenase and may have a downstream effect on IFN-α4 expression.

Mithramycin A

18378-89-7sc-200909
1 mg
$54.00
6
(1)

Binds to GC-rich DNA sequences, potentially inhibiting transcription of genes including IFN-α4.

Rolipram

61413-54-5sc-3563
sc-3563A
5 mg
50 mg
$75.00
$212.00
18
(1)

A phosphodiesterase inhibitor which may result in altered cytokine production, potentially affecting IFN-α4 expression.

Ruxolitinib

941678-49-5sc-364729
sc-364729A
sc-364729A-CW
5 mg
25 mg
25 mg
$246.00
$490.00
$536.00
16
(1)

A JAK1/2 inhibitor that may reduce the JAK-STAT signaling, subsequently decreasing IFN-α4 production.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$80.00
$212.00
$408.00
48
(1)

A TGF-β receptor inhibitor that might modulate immune responses and interfere with IFN-α4 expression.

Silybin

22888-70-6sc-202812
sc-202812A
sc-202812B
sc-202812C
1 g
5 g
10 g
50 g
$54.00
$112.00
$202.00
$700.00
6
(1)

A bioactive compound in milk thistle that has been shown to have regulatory effects on cellular signaling, potentially affecting IFN-α4.