IFI-16 Activators
Common IFI-16 Activators include, but are not limited to Polyinosinic acid - polycytidylic acid sodium salt, double-stranded CAS 42424-50-0, R-848 CAS 144875-48-9, Lipopolysaccharide, E. coli O55:B5 CAS 93572-42-0, Gardiquimod CAS 1020412-43-4 and Imiquimod CAS 99011-02-6.
IFI-16, or Interferon-inducible protein 16, is a multifunctional intracellular protein that belongs to the PYHIN (Pyrin and HIN domain-containing protein) family. Characterized by its ability to recognize viral and host DNA in the cytoplasm, IFI-16 plays a pivotal role in cellular defense mechanisms, particularly in the context of the innate immune response. Upon recognition of aberrant DNA, IFI-16 can initiate a cascade of signaling events leading to the activation of pathways that produce pro-inflammatory cytokines and type I interferons. Beyond its role in DNA sensing, IFI-16 is also involved in the regulation of transcription, cell proliferation, and apoptosis. Given its multifaceted functions, IFI-16 is integral to maintaining cellular homeostasis and orchestrating appropriate responses to both internal and external challenges.
Activators of IFI-16 are molecules or compounds that enhance the activity, stability, or expression of the IFI-16 protein. These activators can function by promoting the DNA-binding capability of IFI-16, by stabilizing its structure, by enhancing its interaction with other signaling components, or by upregulating its expression at the transcriptional or translational level. The presence of IFI-16 activators can lead to potentiation of cellular responses to DNA challenges, amplifying the innate immune response and other processes governed by this protein. Diving deeper into the realm of IFI-16 activators offers a comprehensive view of the delicate balance of intracellular sensing and response mechanisms. As research continues to unfold the myriad pathways and proteins involved in cellular defense and regulation, the role of IFI-16 and its activators emerges as a critical chapter in the narrative of cellular surveillance and protection.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Mimics viral dsRNA and is recognized by TLR3. It can lead to the upregulation of various interferon-stimulated genes, potentially including IFI16. | ||||||
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
An imidazoquinoline compound that activates TLR7 and TLR8, leading to a type I interferon response, which could influence IFI16 expression. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
Recognized by TLR4, LPS can stimulate the production of type I interferons, which may upregulate IFI16 expression. | ||||||
2′,3′-cGAMP | 1441190-66-4 | sc-507484 | 10 mg | $1800.00 | ||
cGAMP is a secondary messenger in the cGAS-STING pathway, which senses cytosolic DNA and leads to type I interferon production, potentially influencing IFI16 expression. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $157.00 $282.00 $516.00 $1177.00 $20138.00 $32779.00 $70753.00 | 1 | |
Another TLR7 agonist; can induce type I interferon responses and potentially upregulate IFI16. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
A TLR7 agonist, it can lead to the activation of type I interferon responses, which may influence IFI16 expression. | ||||||
DMXAA | 117570-53-3 | sc-207592 sc-207592A | 5 mg 25 mg | $129.00 $590.00 | 1 | |
A STING activator, leading to interferon responses which might upregulate IFI16. | ||||||