ICT1 Activators
ICT1 activators are compounds that can potentially influence the expression or activity of Large ribosomal subunit protein mL62, known as ICT1, within the mitochondria. This influence is indirect, arising from the compounds' effects on mitochondrial biogenesis, protein synthesis, and other related pathways rather than direct binding or interaction with the protein itself.
These activators include inhibitors of cytoplasmic or mitochondrial protein synthesis, such as cycloheximide. By inhibiting protein synthesis, it could create a cellular environment where mitochondrial protein synthesis becomes more critical, thereby upregulating the function of ICT1. Compounds like rapamycin, resveratrol, bezafibrate, metformin, and pioglitazone are known to promote mitochondrial biogenesis, which requires increased mitochondrial translation and may, in turn, elevate the demand for ICT1's role in this process. Retinoic acid, through its gene regulatory functions, also has the potential to enhance mitochondrial protein synthesis, including the synthesis of ICT1 itself.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Inhibits eukaryotic protein synthesis, potentially increasing the reliance on mitochondrial protein synthesis and indirectly upregulating ICT1 activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that can lead to increased mitochondrial biogenesis and potentially upregulate ICT1 as part of this process. | ||||||
3′-Azido-3′-deoxythymidine | 30516-87-1 | sc-203319 | 10 mg | $60.00 | 2 | |
A reverse transcriptase inhibitor that can cause mitochondrial toxicity, possibly leading to increased demand for ICT1 in maintaining mitochondrial protein synthesis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Promotes mitochondrial biogenesis, which could indirectly increase the expression and activity of ICT1 within the mitochondria. | ||||||
Bezafibrate | 41859-67-0 | sc-204650B sc-204650 sc-204650A sc-204650C | 500 mg 1 g 5 g 10 g | $30.00 $45.00 $120.00 $200.00 | 5 | |
A peroxisome proliferator-activated receptor (PPAR) agonist that can induce mitochondrial biogenesis, possibly enhancing ICT1 function. | ||||||
Metformin-d6, Hydrochloride | 1185166-01-1 | sc-218701 sc-218701A sc-218701B | 1 mg 5 mg 10 mg | $286.00 $806.00 $1510.00 | 1 | |
An AMPK activator that promotes mitochondrial biogenesis, potentially leading to an increase in ICT1 expression and activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
A PPARγ agonist that can lead to increased mitochondrial biogenesis, potentially influencing ICT1 activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Regulates gene expression and may affect mitochondrial biogenesis, potentially increasing the functional demand on ICT1. | ||||||