Date published: 2025-10-24

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ICT1 Activators

ICT1 activators are compounds that can potentially influence the expression or activity of Large ribosomal subunit protein mL62, known as ICT1, within the mitochondria. This influence is indirect, arising from the compounds' effects on mitochondrial biogenesis, protein synthesis, and other related pathways rather than direct binding or interaction with the protein itself.

These activators include inhibitors of cytoplasmic or mitochondrial protein synthesis, such as cycloheximide. By inhibiting protein synthesis, it could create a cellular environment where mitochondrial protein synthesis becomes more critical, thereby upregulating the function of ICT1. Compounds like rapamycin, resveratrol, bezafibrate, metformin, and pioglitazone are known to promote mitochondrial biogenesis, which requires increased mitochondrial translation and may, in turn, elevate the demand for ICT1's role in this process. Retinoic acid, through its gene regulatory functions, also has the potential to enhance mitochondrial protein synthesis, including the synthesis of ICT1 itself.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Inhibits eukaryotic protein synthesis, potentially increasing the reliance on mitochondrial protein synthesis and indirectly upregulating ICT1 activity.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

An mTOR inhibitor that can lead to increased mitochondrial biogenesis and potentially upregulate ICT1 as part of this process.

3′-Azido-3′-deoxythymidine

30516-87-1sc-203319
10 mg
$60.00
2
(1)

A reverse transcriptase inhibitor that can cause mitochondrial toxicity, possibly leading to increased demand for ICT1 in maintaining mitochondrial protein synthesis.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Promotes mitochondrial biogenesis, which could indirectly increase the expression and activity of ICT1 within the mitochondria.

Bezafibrate

41859-67-0sc-204650B
sc-204650
sc-204650A
sc-204650C
500 mg
1 g
5 g
10 g
$30.00
$45.00
$120.00
$200.00
5
(1)

A peroxisome proliferator-activated receptor (PPAR) agonist that can induce mitochondrial biogenesis, possibly enhancing ICT1 function.

Metformin-d6, Hydrochloride

1185166-01-1sc-218701
sc-218701A
sc-218701B
1 mg
5 mg
10 mg
$286.00
$806.00
$1510.00
1
(1)

An AMPK activator that promotes mitochondrial biogenesis, potentially leading to an increase in ICT1 expression and activity.

Pioglitazone

111025-46-8sc-202289
sc-202289A
1 mg
5 mg
$54.00
$123.00
13
(1)

A PPARγ agonist that can lead to increased mitochondrial biogenesis, potentially influencing ICT1 activity.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Regulates gene expression and may affect mitochondrial biogenesis, potentially increasing the functional demand on ICT1.