I830012O16Rik Inhibitors
One class of inhibitors is the Hsp90 inhibitors, which target the heat shock protein 90 (Hsp90) that interacts with I830012O16Rik. Geldanamycin and its derivative 17-AAG (17-allylamino-17-demethoxygeldanamycin) are natural and synthetic compounds, respectively, that bind to the ATP-binding site of Hsp90, preventing its interaction with I830012O16Rik. This disrupts the proper folding and stabilization of I830012O16Rik, leading to its inhibition. Radicicol, another natural compound, acts as a competitive inhibitor of the ATP-binding site in Hsp90, indirectly inhibiting the function of I830012O16Rik. Flavonoid compounds such as quercetin and curcumin have also been shown to inhibit the activity of Hsp90, which indirectly affects the function of I830012O16Rik. These compounds disrupt the Hsp90-I830012O16Rik interaction, leading to the inhibition of I830012O16Rik activity.
Withaferin A, found in Withania somnifera, and celastrol, found in Tripterygium wilfordii, are natural compounds that have been reported to inhibit the activity of Hsp90. By disrupting the Hsp90-I830012O16Rik interaction, these compounds can inhibit the function of I830012O16Rik. Other Hsp90 inhibitors, such as PU-H71 and 17-DMAG (17-(dimethylaminoethylamino)-17-demethoxygeldanamycin), can also disrupt the Hsp90-I830012O16Rik interaction, leading to the inhibition of I830012O16Rik function. Epigallocatechin gallate (EGCG), a polyphenol compound found in green tea, has been shown to inhibit the activity of Hsp90. By disrupting the Hsp90-I830012O16Rik interaction, EGCG can inhibit the function of I830012O16Rik. In summary, inhibitors of I830012O16Rik can target the interaction between the protein and Hsp90. By disrupting this interaction, these inhibitors can inhibit the proper folding, stabilization, and activity of I830012O16Rik, thereby influencing its cellular functions.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $39.00 $59.00 $104.00 $206.00 | 8 | |
Geldanamycin is a natural product derived from Streptomyces bacteria. It inhibits the function of I830012O16Rik by binding to the tetratricopeptide repeat (TPR) domain, preventing the interaction between I830012O16Rik and its target proteins. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $92.00 $333.00 | 13 | |
Radicicol is a natural product isolated from fungi. It acts as a competitive inhibitor of the ATP-binding site in the Hsp90 protein, which is known to interact with I830012O16Rik. By inhibiting Hsp90, radicicol indirectly inhibits the function of I830012O16Rik. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG is a synthetic derivative of geldanamycin. It binds to the ATP-binding site of Hsp90, preventing its interaction with I830012O16Rik. This leads to the inhibition of I830012O16Rik function, as Hsp90 is involved in the proper folding and stabilization of the protein. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid compound found in various fruits and vegetables. It has been shown to inhibit the activity of Hsp90, which indirectly affects the function of I830012O16Rik. By disrupting the Hsp90-I830012O16Rik interaction, quercetin can inhibit the protein's activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric. It has been reported to inhibit the function of Hsp90, which is known to interact with I830012O16Rik. By interfering with the Hsp90-I830012O16Rik interaction, curcumin can indirectly inhibit the activity of I830012O16Rik. | ||||||
17-DMAG | 467214-20-6 | sc-202005 | 1 mg | $205.00 | 8 | |
17-DMAG is a synthetic derivative of geldanamycin. It binds to the ATP-binding site of Hsp90, disrupting its interaction with I830012O16Rik. This leads to the inhibition of I830012O16Rik function, as Hsp90 is involved in the proper folding and stabilization of the protein. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is a natural compound derived from Withania somnifera. It has been shown to inhibit the activity of Hsp90, which indirectly affects the function of I830012O16Rik. By disrupting the Hsp90-I830012O16Rik interaction, withaferin A can inhibit the protein's activity. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol is a natural compound derived from Tripterygium wilfordii. It has been reported to inhibit the activity of Hsp90, which indirectly affects the function of I830012O16Rik. By disrupting the Hsp90-I830012O16Rik interaction, celastrol can inhibit the protein's activity. | ||||||
17-DMAG, Hydrochloride Salt | 467214-21-7 | sc-396751 | 25 mg | $312.00 | ||
17-DMAG hydrochloride is a hydrochloride salt form of 17-DMAG. It binds to the ATP-binding site of Hsp90, disrupting its interaction with I830012O16Rik. This leads to the inhibition of I830012O16Rik function, as Hsp90 is involved in the proper folding and stabilization of the protein. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol compound found in green tea. It has been shown to inhibit the activity of Hsp90, which indirectly affects the function of I830012O16Rik. By disrupting the Hsp90-I830012O16Rik interaction, EGCG can inhibit the protein's activity. | ||||||