IκB-ε Inhibitors
The chemical class known as IκB-ε Inhibitors encompasses a range of compounds that, while not directly targeting IκB-ε, exert their inhibitory effects through the modulation of various signaling pathways that are integral to the function of IκB-ε. These compounds achieve this by targeting different aspects of the NF-κB pathway or related cellular processes. For instance, inhibitors like BAY 11-7082 and IKK-16 focus on preventing the activation of NF-κB by inhibiting the phosphorylation and degradation of IκB proteins, including IκB-ε. On the other hand, proteasome inhibitors like Bortezomib hinder the degradation process of phosphorylated IκB-ε, thus influencing its function in the NF-κB signaling pathway.
Additionally, compounds such as SP600125, SB203580, and PD98059 target various MAP kinases, which play a pivotal role in signaling cascades that intersect with NF-κB pathways. The modulation of these kinases indirectly impacts IκB-ε's role in NF-κB signaling. Other compounds like Hydroxychloroquine and Anakinra influence NF-κB activity through their effects on Toll-like receptor and cytokine signaling, respectively. Reactive oxygen species inhibitors like N-acetylcysteine and calcium signaling modulators like Verapamil also play a role in indirectly influencing the function of IκB-ε.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
An inhibitor of NF-κB activation, BAY 11-7082 can indirectly inhibit IκB-ε by preventing its phosphorylation and subsequent degradation, which is a prerequisite for NF-κB activation. | ||||||
IKK 16 | 1186195-62-9 | sc-204009 sc-204009A | 10 mg 50 mg | $219.00 $924.00 | 2 | |
As an IKK inhibitor, IKK-16 can indirectly inhibit IκB-ε by blocking the activity of IκB kinase, which is responsible for the phosphorylation and degradation of IκB-ε. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor, Bortezomib can prevent the degradation of phosphorylated IκB-ε, thus indirectly inhibiting its normal function in the NF-κB pathway. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
As a JNK inhibitor, SP600125 can influence NF-κB activity indirectly by modulating JNK-mediated signaling pathways that can affect IκB-ε function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
An inhibitor of p38 MAP kinase, SB203580 can indirectly impact IκB-ε by altering p38 MAP kinase-mediated signaling, which can influence NF-κB activity. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
An ERK inhibitor, PD98059 can indirectly inhibit IκB-ε through its effects on ERK-mediated pathways that intersect with NF-κB signaling. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
By modulating Toll-like receptor signaling, Hydroxychloroquine can indirectly affect NF-κB activity and thereby the function of IκB-ε. | ||||||
Anakinra | 143090-92-0 | sc-507486 | 10 mg | $795.00 | ||
An inhibitor of IL-1, a cytokine that activates NF-κB, Anakinra can indirectly impact IκB-ε function by reducing NF-κB activation through cytokine signaling. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
As a reactive oxygen species inhibitor, N-acetylcysteine can indirectly affect IκB-ε function by modulating the redox state that influences NF-κB signaling. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
A calcium channel blocker, Verapamil can indirectly impact IκB-ε activity by modulating calcium signaling, which is known to influence NF-κB pathway. | ||||||