Hydrocortisone Activators
Hydrocortisone Activators are a collection of chemical compounds that enhance the synthesis and functional activity of Hydrocortisone through various biochemical pathways. The steroid hormone Hydrocortisone is synthesized in the adrenal cortex, and its production can be upregulated by precursors and stimulatory signals. Cholesterol, as a direct precursor, plays a vital role by providing the substrate for cytochrome P450scc, leading to the creation of pregnenolone and subsequent steps in Hydrocortisone biosynthesis.
Compounds such as Adenosine 5'-triphosphate (ATP) are essential as they offer the energy required for steroidogenesis. Furthermore, stimulatory hormones like ACTH from the pituitary gland, and CRH from the hypothalamus, significantly increase Hydrocortisone synthesis by activating the cAMP/PKA pathway. Additionally, Forskolin can mimic ACTH's effect by raising cAMP levels, thereby enhancing the production of Hydrocortisone.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
This compound stimulates the production of cAMP, which in turn activates PKA, thus potentiating Hydrocortisone's regulatory effects on glucose metabolism. | ||||||
BML-275 | 866405-64-3 | sc-200689 sc-200689A | 5 mg 25 mg | $96.00 $355.00 | 69 | |
Inhibits the conversion of cortisone to Hydrocortisone, increasing Hydrocortisone levels, thus enhancing its bioavailability and effects. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
By inhibiting COX, this compound reduces competition for Hydrocortisone's anti-inflammatory actions, allowing for more potent glucocorticoid receptor-mediated effects. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Inhibits mTOR, which may increase the sensitivity of cells to Hydrocortisone's catabolic effects on protein synthesis and metabolism. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
By inhibiting NF-κB, this compound enhances Hydrocortisone's ability to suppress the expression of pro-inflammatory genes. | ||||||