HTLV-1 p24 Inhibitors
HTLV-1 p24, a structural protein encoded by the human T-cell leukemia virus type 1 (HTLV-1), plays a crucial role in viral replication and assembly. This protein is essential for the formation of viral particles and the spread of the virus within the host. Moreover, HTLV-1 p24 has been implicated in immune evasion and modulation of host cell signaling pathways, contributing to the pathogenesis of HTLV-1-associated diseases.
Inhibition of HTLV-1 p24 is a promising strategy for controlling HTLV-1 infection and impeding the progression of associated diseases. Direct inhibitors targeting HTLV-1 p24, such as proteasome inhibitors (e.g., Bortezomib) and histone deacetylase (HDAC) inhibitors (e.g., Vorinostat), disrupt viral protein synthesis and viral replication by blocking essential cellular processes involved in HTLV-1 p24 expression and assembly. Additionally, inhibitors of cellular signaling pathways crucial for HTLV-1 p24 transcription and translation, such as JAK/STAT pathway inhibitors (e.g., Ruxolitinib) and NF-κB inhibitors (e.g., Niclosamide), effectively suppress HTLV-1 p24 production and viral propagation in infected cells. These inhibitors offer promising avenues for combating HTLV-1-associated diseases by targeting HTLV-1 p24 and inhibiting its essential functions in viral replication and pathogenesis.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitor that disrupts proteasomal degradation pathway, leading to accumulation of misfolded proteins and inhibition of HTLV-1 p24 protein degradation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
HDAC inhibitor that prevents chromatin remodeling and transcriptional activation of HTLV-1 p24 gene, leading to inhibition of viral protein expression and replication. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
JAK inhibitor that suppresses JAK/STAT signaling pathway, resulting in downregulation of HTLV-1 p24 gene expression and inhibition of viral protein synthesis. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Hsp90 inhibitor that disrupts chaperone function, leading to degradation of client proteins including HTLV-1 p24, thereby inhibiting viral protein expression and replication. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
Nucleoside analog that inhibits viral DNA synthesis and integration, leading to reduced HTLV-1 p24 production and inhibition of viral replication in infected cells. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
CDK inhibitor that blocks cell cycle progression and viral transcription, leading to downregulation of HTLV-1 p24 expression and inhibition of viral replication. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $37.00 $77.00 $184.00 $510.00 $1224.00 $5814.00 | 8 | |
Inhibits NF-κB activation pathway, resulting in suppression of HTLV-1 p24 transcription and inhibition of viral protein expression and replication in infected cells. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Inhibits thioredoxin reductase, leading to accumulation of reactive oxygen species and inhibition of HTLV-1 p24 expression and viral replication in infected cells. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
BCR-ABL inhibitor that disrupts ABL kinase activity, leading to downregulation of HTLV-1 p24 expression and inhibition of viral protein synthesis in infected cells. | ||||||
Pimozide | 2062-78-4 | sc-203662 | 100 mg | $102.00 | 3 | |
Blocks calcium influx and inhibits NFAT signaling pathway, resulting in suppression of HTLV-1 p24 transcription and inhibition of viral protein expression and replication. | ||||||