HS6ST2 Inhibitors
Chemical inhibitors of HS6ST2 can exert their inhibitory effects through various biochemical interactions and mechanisms. Suramin, for instance, has a broad-spectrum ability to bind to multiple growth factor receptors and enzymes, including sulfotransferases like HS6ST2. By directly binding to the active site or substrate binding site of HS6ST2, Suramin can obstruct the enzyme's normal function, which is essential for transferring sulfate groups to its substrates. Similarly, Triclosan is known for its inhibitory effects on enoyl-acyl carrier protein reductase, and it can also extend this inhibition to other sulfotransferases by interacting with their active sites, leading to the functional inhibition of HS6ST2. Bisphenol A, acting as an endocrine disruptor, can bind to various enzymes and potentially interfere with the enzyme-substrate interactions of HS6ST2, thereby inhibiting its sulfation activity.
Additionally, several polyphenolic compounds exhibit inhibitory actions on protein kinases, which can indirectly inhibit HS6ST2. Flavonoids like Quercetin, Kaempferol, and Genistein, as well as polyphenols like Resveratrol, have the capacity to bind to protein kinases, which could in turn alter the phosphorylation state of HS6ST2 or its substrates, thus affecting HS6ST2's enzymatic activity. Curcumin, known to inhibit a variety of protein kinases, can similarly influence HS6ST2 by changing the phosphorylation patterns of the protein itself or its related proteins. Chlorogenic acid and Ellagic acid, by acting on various enzymes, could interact with the active site or allosteric sites of HS6ST2, potentially inhibiting its function. Catechins like Catechin and Epigallocatechin gallate (EGCG) are known enzyme inhibitors that can engage directly with HS6ST2, preventing its sulfotransferase activity, thereby leading to the loss of its functional capacity to catalyze the transfer of sulfate groups to its specific substrates.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Inhibits various growth factor receptors and enzyme activities, including sulfotransferases. HS6ST2 is a sulfotransferase, so Suramin could inhibit its sulfation activity by directly binding to the enzyme or its substrate binding site, leading to inhibition. | ||||||
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $138.00 $400.00 | ||
Known to inhibit enoyl-acyl carrier protein reductase and possibly other sulfotransferases by binding to their active sites. This could inhibit HS6ST2 by preventing its catalytic action on sulfate group transfer. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Acts as an endocrine disruptor and can bind to various enzymes, potentially inhibiting HS6ST2 by interfering with its enzyme-substrate interactions, leading to functional inhibition. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that can bind to protein kinases and inhibit their activity. HS6ST2 activity could be inhibited if quercetin alters the phosphorylation state of proteins that interact with HS6ST2, thereby affecting its function. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Isoflavone that inhibits protein tyrosine kinases. By inhibiting these kinases, it could alter the phosphorylation state of HS6ST2 or its substrates, leading to functional inhibition of HS6ST2. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Another flavonoid that inhibits various kinases, which could indirectly lead to the functional inhibition of HS6ST2 by altering the phosphorylation of proteins involved in HS6ST2's activity or localization. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Inhibits various protein kinases and could inhibit HS6ST2 by altering the phosphorylation state of the HS6ST2 protein or its associated proteins, thereby affecting its sulfotransferase activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Known to inhibit a wide range of kinases. By inhibiting these kinases, it could prevent the phosphorylation of HS6ST2 or its associated partners, leading to functional inhibition of HS6ST2. | ||||||
Chlorogenic Acid | 327-97-9 | sc-204683 sc-204683A | 500 mg 1 g | $46.00 $68.00 | 1 | |
Acts as an inhibitor of various enzymes and could inhibit HS6ST2 by interacting with its active site or by affecting the enzymes and proteins that regulate the function and stability of HS6ST2. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
A polyphenol that can bind to and inhibit the activity of a variety of enzymes. It could inhibit HS6ST2's sulfotransferase activity by direct interaction with its active site or allosteric sites. | ||||||