HOTTL Inhibitors
HOTTL inhibitors are chemical compounds that specifically target and inhibit the function of HOTTL (Histone octamer transfer to lysine), a protein involved in chromatin remodeling and histone modifications. HOTTL plays a crucial role in regulating the dynamics of chromatin structure, which is essential for processes such as gene expression, DNA replication, and repair. By mediating the transfer of histones and their subsequent post-translational modifications, HOTTL helps control the accessibility of DNA to transcription factors and other proteins involved in genetic regulation. Inhibiting HOTTL disrupts its ability to manage histone modifications and chromatin assembly, leading to changes in chromatin structure and potentially affecting gene expression.
Researchers utilize HOTTL inhibitors to study the role of this protein in chromatin organization and how its activity influences epigenetic regulation. By blocking HOTTL, scientists can explore the downstream effects on histone modifications, such as methylation and acetylation, and observe how these alterations impact chromatin dynamics and gene transcription. These inhibitors provide valuable insights into the mechanisms that control the packaging and accessibility of genetic material, helping to understand the broader role of chromatin remodeling in various cellular processes. The study of HOTTL inhibitors also contributes to the understanding of epigenetic modifications and how they affect cellular identity, differentiation, and response to environmental stimuli. Through such research, HOTTL inhibitors serve as powerful tools for uncovering the molecular mechanisms that govern chromatin structure and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide could downregulate HOTTL expression by directly inhibiting RNA polymerase II, the enzyme responsible for transcribing most eukaryotic genes, including TTLL3. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
Actinomycin D might decrease HOTTL mRNA synthesis by binding to DNA sequences at the transcription initiation complex, obstructing the transcriptional journey of RNA polymerase. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin may decrease HOTTL protein levels by inhibiting the mTOR pathway, which is crucial for initiating cap-dependent translation, a process necessary for TTLL3 protein synthesis. | ||||||
Mycophenolate mofetil | 128794-94-5 | sc-200971 sc-200971A | 20 mg 100 mg | $37.00 $109.00 | 1 | |
Mycophenolate mofetil could reduce the synthesis of HOTTL by depleting guanine nucleotides, essential building blocks for RNA and DNA, thereby hindering RNA transcription. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine may lead to decreased HOTTL expression by causing DNA demethylation, which can alter gene expression patterns of various genes, including the TTLL3 gene. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Suberoylanilide Hydroxamic Acid could inhibit HOTTL expression by promoting histone acetylation, resulting in chromatin remodeling and subsequent transcriptional repression of TTLL3. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
α-Amanitin may inhibit the production of HOTTL by selectively inhibiting RNA polymerase II during mRNA transcription, leading to a decrease in TTLL3 mRNA. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine might decrease HOTTL expression by intercalating into DNA and RNA, disrupting nucleic acid synthesis and repair, and thus potentially hindering TTLL3 mRNA synthesis. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate could reduce HOTTL expression by inhibiting dihydrofolate reductase, leading to decreased availability of thymidine and purine, and consequently reducing TTLL3 transcription. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB could decrease HOTTL mRNA levels by inhibiting the phosphorylation of RNA polymerase II, thereby stalling the elongation process of TTLL3 gene transcription. | ||||||