HMG-1 Inhibitors
Common HMG-1 Inhibitors include, but are not limited to Glycyrrhizic acid CAS 1405-86-3, Ethyl pyruvate CAS 617-35-6, Quercetin CAS 117-39-5, Necrostatin-1 CAS 4311-88-0 and Salicylic acid CAS 69-72-7.
HMG-1 inhibitors belong to a chemical class of compounds designed to selectively target and inhibit the function of High Mobility Group Box 1 (HMG-1), a protein that plays a critical role in various cellular processes. HMG-1 is a member of the high mobility group (HMG) protein family, which are non-histone architectural proteins that interact with DNA and play a role in regulating gene expression and chromatin structure. HMG-1 is known to function both inside the cell nucleus and outside the cell, where it can contribute to inflammatory responses and immune regulation.
Inhibiting HMG-1 aims to disrupt its interactions with DNA and other cellular components, affecting its role in gene regulation, DNA repair, and inflammation. By modulating the function of HMG-1, these inhibitors impact various cellular processes that involve HMG-1's interactions with DNA and other proteins. The development of HMG-1 inhibitors offers a way to investigate the specific functions and molecular interactions of HMG-1, shedding light on its diverse roles in both normal physiological processes and disease conditions. Understanding the intricate mechanisms by which HMG-1 operates can provide insights into cellular dynamics and molecular pathways that may have broader implications for scientific research and applications.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $56.00 $326.00 | 7 | |
Glycyrrhizin is a natural compound that might inhibit HMGB1 by interacting with its DNA-binding domains, modulating its pro-inflammatory and immune-modulating functions. | ||||||
Ethyl pyruvate | 617-35-6 | sc-257508 | 25 g | $32.00 | 2 | |
Ethyl pyruvate is a small molecule that could inhibit HMGB1 by suppressing its release and dampening its pro-inflammatory activities, potentially alleviating inflammation-related conditions. | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $149.00 $210.00 $714.00 $2550.00 $10750.00 $21410.00 $40290.00 | 5 | |
Although more documented in the context of HMGA2, Suramin is expected to inhibit HMGA1 as well, by binding to the "AT-hook" DNA-binding motifs, and therefore preventing HMGA1 proteins from binding to the minor groove of AT-rich DNA sequences, similar to the action of Distamycin A. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Ruxolitinib isn't a direct inhibitor of HMGA1, but it's noted that HMGA1 depletion enhances responses to this JAK2 inhibitor, preventing myelofibrosis (MF) and prolonging survival in murine models of JAK2V617F acute myeloid leukemia (AML). This suggests a potential synergistic or indirect inhibition mechanism via other molecular targets. | ||||||
Nystatin | 1400-61-9 | sc-212431 sc-212431A sc-212431B sc-212431C | 5 MU 25 MU 250 MU 5000 MU | $50.00 $126.00 $246.00 $3500.00 | 7 | |
Nystatin is an antifungal agent that might inhibit HMGB1 by disrupting its binding to Toll-like receptors (TLRs), attenuating inflammation and immune responses. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a natural flavonoid that could inhibit HMGB1 by suppressing its release and pro-inflammatory activities, potentially attenuating inflammation-related disorders. | ||||||
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $92.00 $336.00 | 97 | |
Necrostatin-1 is a compound that might inhibit HMGB1 release by modulating the necroptosis pathway, potentially impacting inflammation and cell death. | ||||||
Salicylic acid | 69-72-7 | sc-203374 sc-203374A sc-203374B | 100 g 500 g 1 kg | $46.00 $92.00 $117.00 | 3 | |
Salicylic acid is a potential HMGB1 inhibitor that might suppress its release and dampen its pro-inflammatory activities, potentially mitigating inflammation-related conditions. | ||||||
Hemicholinium-3 | 312-45-8 | sc-252873 sc-252873A | 100 mg 500 mg | $82.00 $405.00 | ||
Hemicholinium-3 (HC-3) is a compound that might inhibit HMGB1 by interfering with its interactions with nucleic acids, potentially attenuating its pro-inflammatory functions. | ||||||
Ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno [2,3-c]pyridine-3-carboxylate | 24237-54-5 | sc-285521 sc-285521A | 5 g 25 g | $188.00 $525.00 | ||
Tinoridine is a potential HMGB1 inhibitor that might impact its release and pro-inflammatory activities, potentially alleviating inflammatory conditions. | ||||||