HL60 Antigen Inhibitors
HL60 antigen inhibitors represent a class of compounds primarily studied for their role in modulating specific cellular processes associated with the HL60 cell line. HL60 cells are human promyelocytic leukemia cells that are often used as a model system for studying myeloid differentiation and various immunological pathways. These inhibitors target antigens expressed on the surface of HL60 cells, affecting the molecular and biochemical signaling cascades essential for cell differentiation, proliferation, and apoptosis. By inhibiting these antigens, researchers can explore fundamental mechanisms of cell surface receptor interactions, including how external signals influence intracellular events such as gene expression, protein modification, and cytoskeletal rearrangements.
The study of HL60 antigen inhibitors is of particular interest in understanding the regulation of immune responses, cellular adhesion, and the interplay between different types of signaling molecules like cytokines, chemokines, and growth factors. These inhibitors can be used to dissect the dynamics of receptor-mediated endocytosis, antigen presentation, and the subsequent activation or suppression of intracellular pathways. Additionally, they offer a unique tool to examine how changes in the microenvironment, such as the presence of specific antigens or binding molecules, influence cell behavior. The manipulation of antigen expression or inhibition allows for the detailed study of differentiation into granulocytes or monocytes and the investigation of cell signaling networks, offering a broad platform for the exploration of cellular biology at the molecular level.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Suberoylanilide Hydroxamic Acid may downregulate the expression of HL60 Antigen by causing the acetylation of histones, which leads to a more relaxed chromatin structure and a subsequent decrease in the transcriptional activity of certain genes. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
5-Aza-2′-Deoxycytidine could reduce HL60 Antigen levels by incorporating into DNA and trapping DNA methyltransferases, thereby decreasing DNA methylation and altering the expression of genes that control the antigen's production. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid has the potential to decrease the expression of HL60 Antigen by binding to retinoic acid receptors (RARs), which then heterodimerize with retinoid X receptors (RXRs) and bind to retinoic acid response elements (RAREs) in the DNA, leading to changes in gene transcription patterns. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may inhibit the expression of HL60 Antigen by specifically blocking the activity of histone deacetylases, thus disrupting the removal of acetyl groups from histones, affecting the transcription of genes involved in cell cycle progression and apoptosis. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $87.00 $224.00 | ||
Arsenic trioxide might downregulate HL60 Antigen expression by promoting morphological changes and partial differentiation of promyelocytes to granulocytes, which could involve the repression of genes associated with the undifferentiated state. | ||||||
Idarubicin | 58957-92-9 | sc-507346 | 10 mg | $180.00 | ||
Idarubicin might decrease the expression of HL60 Antigen by intercalating into DNA, thus blocking the replication fork and transcriptional machinery, leading to a cessation of nucleic acid synthesis and subsequently reduced protein expression. | ||||||
1-β-D-Arabinofuranosylcytosine | 147-94-4 | sc-201628 sc-201628A sc-201628B sc-201628C sc-201628D | 1 g 5 g 25 g 100 g 250 g | $147.00 $258.00 $508.00 $717.00 $1432.00 | 1 | |
1-β-D-Arabinofuranosylcytosine could inhibit the expression of HL60 Antigen by acting as a nucleoside analog, impairing DNA polymerase action during S-phase, leading to DNA strand breaks and effective downregulation of DNA replication-dependent gene expression. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Imatinib might inhibit HL60 Antigen expression by targeting specific tyrosine kinases, disrupting signal transduction pathways that would otherwise promote the transcription of genes involved in cell growth and survival. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol may reduce the expression of HL60 Antigen by competitively inhibiting cyclin-dependent kinases, leading to a blockade of cell cycle progression at the G1 phase and prevention of the upregulation of genes required for entering S-phase. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Bortezomib could suppress HL60 Antigen production by preventing the degradation of ubiquitin-tagged proteins, including those that control cell cycle checkpoints and apoptosis, thereby altering the cell's protein equilibrium and gene expression profiles. | ||||||